Reductive effect of body weight in C57BL/6J mice fed a high-fat diet by Saesaengmyung Diet

• Published in: Canadian journal of physiology and pharmacology Vol. 83; no. 2; pp. 161 - 165
• Main Authors: An, Hyo-Jin, Kim, Na-Hyung, Kim, Yun-Kyung, Lyu, Yeoung-Su, Shin, Taekyun, Hong, Seung-Heon, Kim, Hyung-Min
• Format: Journal Article
• Language: English
• Published: Ottawa, Canada NRC Research Press 01.02.2005; National Research Council of Canada; Canadian Science Publishing NRC Research Press
• Subjects: Alanine Transaminase - blood; Animals; Aspartate Aminotransferases - blood; Biological and medical sciences; Blood Glucose - analysis; Cholesterol - blood; Diet; Dietary Fats - administration & dosage; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Male; Mice; Mice, Inbred C57BL; Plant Preparations - pharmacology; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Weight Loss; Body weight; Rodentia; Lipids; Corporal biometry; Supplemented diet; Feeding; Dietetic product; Vertebrata; Mammalia; Mouse; Fat; Nutritional status; Glycemia
• ISSN: 0008-4212; 1205-7541
• DOI: 10.1139/y04-135

The Saesaengmyung Diet (SD) is a newly developed dietary product to help control weight. The aim of this study was to evaluate whether SD combined with a high-fat (HF) diet could influence body weight, fat accumulation, and glucose levels in blood. C57BL/6J mice were fed for 8 weeks with a standard diet, an HF diet, and an HF + 10% or HF + 20% SD diet. Body weight was recorded weekly, and plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and glucose were analyzed at the end of the study. Weight increases in the 10% or 20% SD group were significantly less than in the HF diet group (p < 0.05). Plasma total cholesterol level significantly decreased by 33.5% in the 10% SD group and 38.8% in the 20% SD group, but the LDL cholesterol, HDL cholesterol, and glucose levels in the SD groups were not significantly changed. Our findings indicate that SD may be beneficial to overweight individuals in the reduction of weight gain induced by an HF diet.Key words: Saesaengmyung Diet, high-fat diet, obesity, body weight, cholesterol, glucose.