Resective Surgery versus Debridement in Stage 2 Medication-Related Osteonecrosis of the Jaw

The aim of this study is to analyze surgical and functional outcomes in order to verify the applicability of surgical treatment guidelines as foreseen by MASCC/ISOO/ASCO 2019. Patients affected by stage 2 MRONJ refractory to conservative management were grouped if underwent surgical resection (Group...

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Published inApplied sciences Vol. 11; no. 18; p. 8553
Main Authors D’Amato, Salvatore, Troiano, Antonio, Lo Giudice, Giorgio, De Cicco, Davide, Rusciano, Mario, Tartaro, Gianpaolo, Colella, Giuseppe
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2021
Subjects
Acids
Antibiotics
Biomedical materials
Bisphosphonates
BRONJ
Cancer therapies
Classification
Debridement
Fistula
General anesthesia
Inflammation
medication-related osteonecrosis of the jaw
MRONJ
Oral hygiene
Osteonecrosis
Osteoporosis
Patient education
Patients
Quality of life
Questionnaires
resective surgery
Software
Statistical analysis
Surgery
United States > US
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Abstract The aim of this study is to analyze surgical and functional outcomes in order to verify the applicability of surgical treatment guidelines as foreseen by MASCC/ISOO/ASCO 2019. Patients affected by stage 2 MRONJ refractory to conservative management were grouped if underwent surgical resection (Group A) or debridement (Group B). Health-related quality of life was evaluated by using the European Organization for Research and Treatment of Cancer questionnaires, QLQ-C30 and H&N35. Statistical analysis was performed using Wilcoxon/Mann–Whitney test, Kaplan–Meier test, Cox regression model and Cox multivariate regression. Group A showed higher complete healing cases vs. group B. Recurrence rate difference in group A vs. group B was statistically significant. Debridement is an unfavorable prognostic factor when compared to surgical resection (p = 0.0032, HR 4.9). Quality of life mean values showed a marked improvement in Group A and a slight improvement in Group B. Debridement has 4.9 times more risk to develop recurrence when compared to surgical resection. A more satisfactory quality of life was shown in patients subject to resective surgery with an improving trend from baseline. Debridement patients showed more variability of results and an overall negative trend at the end of the 6-month follow-up.
AbstractList The aim of this study is to analyze surgical and functional outcomes in order to verify the applicability of surgical treatment guidelines as foreseen by MASCC/ISOO/ASCO 2019. Patients affected by stage 2 MRONJ refractory to conservative management were grouped if underwent surgical resection (Group A) or debridement (Group B). Health-related quality of life was evaluated by using the European Organization for Research and Treatment of Cancer questionnaires, QLQ-C30 and H&N35. Statistical analysis was performed using Wilcoxon/Mann–Whitney test, Kaplan–Meier test, Cox regression model and Cox multivariate regression. Group A showed higher complete healing cases vs. group B. Recurrence rate difference in group A vs. group B was statistically significant. Debridement is an unfavorable prognostic factor when compared to surgical resection (p = 0.0032, HR 4.9). Quality of life mean values showed a marked improvement in Group A and a slight improvement in Group B. Debridement has 4.9 times more risk to develop recurrence when compared to surgical resection. A more satisfactory quality of life was shown in patients subject to resective surgery with an improving trend from baseline. Debridement patients showed more variability of results and an overall negative trend at the end of the 6-month follow-up.
Author Colella, Giuseppe
Rusciano, Mario
De Cicco, Davide
D’Amato, Salvatore
Troiano, Antonio
Lo Giudice, Giorgio
Tartaro, Gianpaolo
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CitedBy_id crossref_primary_10_1016_j_jcms_2024_01_007
crossref_primary_10_1097_SCS_0000000000008719
crossref_primary_10_3390_diagnostics13132137
crossref_primary_10_3390_app112311195
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SubjectTerms Acids
Antibiotics
Biomedical materials
Bisphosphonates
BRONJ
Cancer therapies
Classification
Debridement
Fistula
General anesthesia
Inflammation
medication-related osteonecrosis of the jaw
MRONJ
Oral hygiene
Osteonecrosis
Osteoporosis
Patient education
Patients
Quality of life
Questionnaires
resective surgery
Software
Statistical analysis
Surgery
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Title Resective Surgery versus Debridement in Stage 2 Medication-Related Osteonecrosis of the Jaw
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