The use and development of retroviral vectors to deliver cytokine genes for cancer therapy

In this review, we describe technical advancements of retroviral vectors to address issues of safety, titer, and clinical scale manufacturing to produce high-quality retroviral vector preparations that have made direct intratumoral administration of cytokine encoding recombinant vectors a feasible c...

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Bibliographic Details
Published inCritical reviews in therapeutic drug carrier systems Vol. 17; no. 1; p. 1
Main Authors Fong, T C, Sauter, S L, Ibañez, C E, Sheridan, P L, Jolly, D J
Format Journal Article
LanguageEnglish
Published United States 2000
Subjects
Cytokines - genetics
Genetic Vectors - adverse effects
Genetic Vectors - standards
Humans
Neoplasms - therapy
Retroviridae - genetics
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Summary:In this review, we describe technical advancements of retroviral vectors to address issues of safety, titer, and clinical scale manufacturing to produce high-quality retroviral vector preparations that have made direct intratumoral administration of cytokine encoding recombinant vectors a feasible cancer therapy in the clinic. We also review possible further advances in retroviral vector design, which may prove important in expanding these clinical applications.
ISSN:0743-4863
DOI:10.1615/critrevtherdrugcarriersyst.v17.i1.10