Full-thickness skin necrosis after arginine extravasation—a case report and review of literature

The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin necrosis that requires serious surgical intervention with aesthetic and functional sequellea. The authors describe a case of distal forearm skin nec...

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Published inJournal of pediatric surgery Vol. 39; no. 4; pp. e9 - e11
Main Authors Salameh, Yousef, Shoufani, Aziz
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2004
Subjects
Arginine - adverse effects
Arginine test
Child, Preschool
Debridement
Drug Eruptions - etiology
Drug Eruptions - pathology
Drug Eruptions - surgery
Dwarfism, Pituitary - diagnosis
extravasation injuries
Extravasation of Diagnostic and Therapeutic Materials - pathology
Extravasation of Diagnostic and Therapeutic Materials - surgery
Female
groin flap
Human Growth Hormone - metabolism
Humans
hyaluronidase
Infusions, Intravenous - adverse effects
Necrosis
Skin - injuries
Skin - pathology
skin necrosis
Skin Transplantation
Surgical Flaps
Wrist
skin necrosis
hyaluronidase
groin flap
Arginine test
extravasation injuries
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Abstract The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin necrosis that requires serious surgical intervention with aesthetic and functional sequellea. The authors describe a case of distal forearm skin necrosis caused by arginine extravasation that was treated by wide debridement and a combination of groin flap and later with split-thickness skin graft. The authors emphasize the need for early and active management of arginine extravasation injuries.
AbstractList The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin necrosis that requires serious surgical intervention with aesthetic and functional sequellea. The authors describe a case of distal forearm skin necrosis caused by arginine extravasation that was treated by wide debridement and a combination of groin flap and later with split-thickness skin graft. The authors emphasize the need for early and active management of arginine extravasation injuries.
Author Shoufani, Aziz
Salameh, Yousef
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Cites_doi 10.1007/BF03343686
10.1016/0007-1226(91)90071-Q
10.1097/00006534-199803000-00030
10.1016/0007-1226(84)90035-3
10.7326/0003-4819-89-5-632
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10.1016/0007-1226(93)90137-Z
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10.1016/S0140-6736(85)92678-9
10.1054/bjps.2001.3593
10.1097/00007611-199103000-00018
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Issue 4
Keywords skin necrosis
hyaluronidase
groin flap
Arginine test
extravasation injuries
Language English
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Snippet The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin...
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SubjectTerms Arginine - adverse effects
Arginine test
Child, Preschool
Debridement
Drug Eruptions - etiology
Drug Eruptions - pathology
Drug Eruptions - surgery
Dwarfism, Pituitary - diagnosis
extravasation injuries
Extravasation of Diagnostic and Therapeutic Materials - pathology
Extravasation of Diagnostic and Therapeutic Materials - surgery
Female
groin flap
Human Growth Hormone - metabolism
Humans
hyaluronidase
Infusions, Intravenous - adverse effects
Necrosis
Skin - injuries
Skin - pathology
skin necrosis
Skin Transplantation
Surgical Flaps
Wrist
Title Full-thickness skin necrosis after arginine extravasation—a case report and review of literature
URI https://dx.doi.org/10.1016/j.jpedsurg.2003.12.030
https://www.ncbi.nlm.nih.gov/pubmed/15065075
Volume 39
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