Full-thickness skin necrosis after arginine extravasation—a case report and review of literature

The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin necrosis that requires serious surgical intervention with aesthetic and functional sequellea. The authors describe a case of distal forearm skin nec...

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Bibliographic Details
Published inJournal of pediatric surgery Vol. 39; no. 4; pp. e9 - e11
Main Authors Salameh, Yousef, Shoufani, Aziz
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2004
Subjects
Arginine - adverse effects
Arginine test
Child, Preschool
Debridement
Drug Eruptions - etiology
Drug Eruptions - pathology
Drug Eruptions - surgery
Dwarfism, Pituitary - diagnosis
extravasation injuries
Extravasation of Diagnostic and Therapeutic Materials - pathology
Extravasation of Diagnostic and Therapeutic Materials - surgery
Female
groin flap
Human Growth Hormone - metabolism
Humans
hyaluronidase
Infusions, Intravenous - adverse effects
Necrosis
Skin - injuries
Skin - pathology
skin necrosis
Skin Transplantation
Surgical Flaps
Wrist
skin necrosis
hyaluronidase
groin flap
Arginine test
extravasation injuries
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Summary:The arginine test is highly useful in the evaluation of short-stature children and adolescents. Extravasation of arginine can cause full-thickness skin necrosis that requires serious surgical intervention with aesthetic and functional sequellea. The authors describe a case of distal forearm skin necrosis caused by arginine extravasation that was treated by wide debridement and a combination of groin flap and later with split-thickness skin graft. The authors emphasize the need for early and active management of arginine extravasation injuries.
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2003.12.030