Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia

• Published in: Neuromodulation (Malden, Mass.) Vol. 26; no. 5; pp. 999 - 1008
• Main Authors: Lim, Manyoel, Kim, Dajung J., Nascimento, Thiago D., Ichesco, Eric, Kaplan, Chelsea, Harris, Richard E., DaSilva, Alexandre F.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2023
• Subjects: Brain signal variability; brain stimulation; Cross-Over Studies; Female; fibromyalgia; Fibromyalgia - diagnostic imaging; Fibromyalgia - therapy; Humans; Magnetic Resonance Imaging; Pain; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiology; resting-state fMRI; tDCS; Transcranial Direct Current Stimulation - methods; brain stimulation; Brain signal variability; resting-state fMRI; fibromyalgia; tDCS
• ISSN: 1094-7159; 1525-1403; 1525-1403
• DOI: 10.1111/ner.13512

Although primary motor cortex (M1) transcranial direct current stimulation (tDCS) has an analgesic effect in fibromyalgia (FM), its neural mechanism remains elusive. We investigated whether M1-tDCS modulates a regional temporal variability of blood-oxygenation-level-dependent (BOLD) signals, an indicator of the brain's flexibility and efficiency and if this change is associated with pain improvement. In a within-subjects cross-over design, 12 female FM patients underwent sham and active tDCS on five consecutive days, respectively. Each session was performed with an anode placed on the left M1 and a cathode on the contralateral supraorbital region. The subjects also participated in resting-state functional magnetic resonance imaging (fMRI) at baseline and after sham and active tDCS. We compared the BOLD signal variability (SDBOLD), defined as the standard deviation of the BOLD time-series, between the tDCS conditions. Baseline SDBOLD was compared to 15 healthy female controls. At baseline, FM patients showed reduced SDBOLD in the ventromedial prefrontal cortex (vmPFC), lateral PFC, and anterior insula and increased SDBOLD in the posterior insula compared to healthy controls. After active tDCS, compared to sham, we found an increased SDBOLD in the left rostral anterior cingulate cortex (rACC), lateral PFC, and thalamus. After sham tDCS, compared to baseline, we found a decreased SDBOLD in the dorsomedial PFC and posterior cingulate cortex/precuneus. Interestingly, after active tDCS compared to sham, pain reduction was correlated with an increased SDBOLD in the rACC/vmPFC but with a decreased SDBOLD in the posterior insula. Our findings suggest that M1-tDCS might revert temporal variability of fMRI signals in the rACC/vmPFC and posterior insula linked to FM pain. Changes in neural variability would be part of the mechanisms underlying repetitive M1-tDCS analgesia in FM.