Investigation of THz Absorptive Signatures in Opioids

We investigate the possibility of sensing opioid drugs, such as fentanyl, by their THz electromagnetic signatures. The methods include both computer modeling and experiments. Molecular dynamics simulations predict that fentanyl should display THz resonances, with several of them occurring below 1.0...

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Bibliographic Details
Published inApplied sciences Vol. 12; no. 1; p. 61
Main Authors Zhang, Weidong, Bykhovski, Alexei, Brown, Elliott R.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.01.2022
Subjects
Absorptivity
Analgesics
Cocaine
Drugs
Fentanyl
Heroin
Investigations
Lactose
Molecular dynamics
molecular dynamics modeling
Morphine
Narcotics
Opioids
Oxycodone
Pharmaceuticals
sensing
Simulation
Spectroscopy
Spectrum analysis
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Summary:We investigate the possibility of sensing opioid drugs, such as fentanyl, by their THz electromagnetic signatures. The methods include both computer modeling and experiments. Molecular dynamics simulations predict that fentanyl should display THz resonances, with several of them occurring below 1.0 THz; the lowest one is at around 0.337 THz (337 GHz). Spectroscopy measurements were conducted on oxycodone, which was used as a surrogate for fentanyl. They display vibrational absorption resonances between ∼1.4 and 1.6 THz.
ISSN:2076-3417
2076-3417
DOI:10.3390/app12010061