Local spinal cord blood flow in experimental traumatic myelopathy

Focal blood flow was measured in the lateral funiculus and center of the spinal cord in the rhesus monkey both before and after a 600 gm-cm injury at T-10. Measurements made by the hydrogen clearance technique showed that blood flow in the lateral funiculus more than doubled within 4 hours after inj...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 42; no. 2; p. 144
Main Authors Kobrine, A I, Doyle, T F, Martins, A N
Format Journal Article
LanguageEnglish
Published United States 01.02.1975
Subjects
Animals
Blood Circulation Time
Infarction - etiology
Ischemia - etiology
Macaca mulatta
Paraplegia - etiology
Spinal Cord - blood supply
Spinal Cord Injuries - complications
Spinal Cord Injuries - physiopathology
Thoracic Vertebrae - injuries
Time Factors
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Summary:Focal blood flow was measured in the lateral funiculus and center of the spinal cord in the rhesus monkey both before and after a 600 gm-cm injury at T-10. Measurements made by the hydrogen clearance technique showed that blood flow in the lateral funiculus more than doubled within 4 hours after injury, returned to normal by 8 hours, and remained in the normal range for 24 hours. At no time was a hypoperfusion in the lateral funiculus present. Blood flow in the center of the spinal cord, at the level of the lesion, began to fall within 1 hour following injury and continued to fall for 4 hours. These data challenge the notion that spreading ischemia of the white matter is an important factor in the pathophysiology of experimental spinal cord injury.
ISSN:0022-3085
1933-0693
DOI:10.3171/jns.1975.42.2.0144