Quantum Molecular Modeling of the Elastinic Tetrapeptide Val-Pro-Gly-Gly

The free Val-Pro-Gly-Gly tetrapeptide belonging to the Proline-rich sequences of elastin has been studied both theoretically and experimentally. The molecular modelisation was carried out using AM1 and ab initio quantum computations while the conformation in solution was ascertained by circular dich...

Full description

Saved in:
Bibliographic Details
Published inJournal of biomolecular structure & dynamics Vol. 15; no. 6; pp. 1073 - 1091
Main Authors Broch, H., Moulabbi, M., Vasilescu, D., Tamburro, A. M.
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Group 01.06.1998
Subjects
Elastin - chemistry
Glycine
Models, Molecular
Oligopeptides - chemistry
Proline
Protein Conformation
Valine
Online AccessGet full text

Cover

More Information
Summary:The free Val-Pro-Gly-Gly tetrapeptide belonging to the Proline-rich sequences of elastin has been studied both theoretically and experimentally. The molecular modelisation was carried out using AM1 and ab initio quantum computations while the conformation in solution was ascertained by circular dichroism spectroscopy performed on the synthesized tetrapeptide. Experimental and theoretical investigations lead to the conclusion that the most probable structure is constituted by a type II β-turn.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0739-1102
1538-0254
DOI:10.1080/07391102.1998.10509002