Visceral and cutaneous leishmaniasis in an European paediatric population

Six children with leishmaniasis, aged 10 months to 10 years, were treated in the Paediatric Department. Four patients had visceral leishmaniasis (kala-azar): diagnosis was based on bone marrow examination and therapy consisted of a combination of Glucantime and Lomidine. The remaining two children h...

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Bibliographic Details
Published inActa clinica belgica (English ed. Online) Vol. 47; no. 4; p. 231
Main Authors Mattot, M, Ninane, J, Bigaignon, G, Vermylen, C, Cornu, G
Format Journal Article
LanguageEnglish
Published England 1992
Subjects
Animals
Antiprotozoal Agents - therapeutic use
Bone Marrow - parasitology
Child
Child, Preschool
Drug Therapy, Combination
Female
Humans
Infant
Leishmania - isolation & purification
Leishmaniasis, Cutaneous - drug therapy
Leishmaniasis, Cutaneous - parasitology
Leishmaniasis, Visceral - drug therapy
Male
Meglumine - administration & dosage
Meglumine Antimoniate
Organometallic Compounds - administration & dosage
Pentamidine - administration & dosage
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Summary:Six children with leishmaniasis, aged 10 months to 10 years, were treated in the Paediatric Department. Four patients had visceral leishmaniasis (kala-azar): diagnosis was based on bone marrow examination and therapy consisted of a combination of Glucantime and Lomidine. The remaining two children had cutaneous leishmaniasis: diagnosis was made by skin biopsy and the patients were treated with Glucantime alone. In all children, serology was clearly positive at the time of the diagnosis and all patients improved. The only side effects were cough associated with fever in one child, and supraventricular premature beats in another one. They were ascribed to Glucantime, and proved reversible after discontinuation of the treatment.
ISSN:1784-3286
DOI:10.1080/17843286.1992.11718236