Septic Shock, Community-acquired Pneumonia, New-Onset Atrial Fibrillation, and Intensive Care Unit Outcomes

Since the original study by Rivers and colleagues (single center; n= 263) in 2001 (2), early goal-directed therapy (EGDT) has been endorsed by the Surviving Sepsis Campaign and is considered by many to be the standard of care for septic shock or severe sepsis. However, its clinical effectiveness rem...

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Bibliographic Details
Published inAmerican journal of respiratory and critical care medicine Vol. 192; no. 5; pp. 629 - 631
Main Authors Xue, Bing, Chugh, Karan, Bhanot, Ravinder, Sankari, Abdulghani
Format Journal Article
LanguageEnglish
Published United States American Thoracic Society 01.09.2015
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Summary:Since the original study by Rivers and colleagues (single center; n= 263) in 2001 (2), early goal-directed therapy (EGDT) has been endorsed by the Surviving Sepsis Campaign and is considered by many to be the standard of care for septic shock or severe sepsis. However, its clinical effectiveness remains uncertain, and its supporting evidence is lacking in the light of recent Pr°CESS trial (31 centers; n = 1,341) (3), which demonstrated that a strict EGDT protocol for early septic shock did not improve outcomes over a usual-care group. 9 references
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ObjectType-Evidence Based Healthcare-3
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ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201504-0689RR