Efficacy of once daily bisoprolol in stable angina pectoris: an objective comparison with atenolol and long term follow-up

• Published in: European heart journal Vol. 6; no. 10; p. 845
• Main Authors: Kohli, R S, Khurmi, N S, Kardash, M M, Hughes, L O, Lahiri, A, Raftery, E B
• Format: Journal Article
• Language: English
• Published: England 01.10.1985
• Subjects: Administration, Oral; Adrenergic beta-Antagonists - adverse effects; Adrenergic beta-Antagonists - therapeutic use; Adult; Aged; Angina Pectoris - drug therapy; Atenolol - adverse effects; Atenolol - therapeutic use; Bisoprolol; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Exercise Test; Female; Follow-Up Studies; Hemodynamics - drug effects; Humans; Male; Middle Aged; Propanolamines - adverse effects; Propanolamines - therapeutic use; Random Allocation
• ISSN: 0195-668X
• DOI: 10.1093/oxfordjournals.eurheartj.a061771

Bisoprolol is a new cardioselective beta-blocker with a long half-life. The efficacy of once daily bisoprolol (10 mg) and atenolol (100 mg) was assessed in 20 patients with stable angina using a placebo controlled double-blind randomized crossover protocol. Efficacy was assessed by computer assisted treadmill exercise testing with monitoring of leads CM5 and CC5, carried out 22-24 h after the last dose. The mean +/- SEM exercise time on placebo was 6.5 +/- 0.4 min increasing to 7.8 +/- 0.5 min on bisoprolol (P less than 0.001) and 8.6 +/- 0.6 mins on atenolol (P less than 0.001). The time to 1 mm ST depression in CM5 and CC5 was also prolonged significantly with both drugs. The mean basal resting heart rate of 84 +/- 4 bpm decreased to 63 +/- 2 bpm on bisoprolol (P less than 0.001) and 64 +/- 3 bpm on atenolol (P less than 0.001), with a significant decrease in the peak exercise heart rate seen with both drugs (P less than 0.001). The peak rate-pressure product was 175 +/- 8 after placebo, 146 +/- 7 (P less than 0.001) with bisoprolol and 149 +/- 5 (P less than 0.001) after atenolol. One patient was withdrawn because he suffered a myocardial infarction. Eighteen patients were prescribed bisoprolol 10 mg once a day for 6 weeks and an exercise test was performed at the end of this period. Bisoprolol retained its efficacy at the end of this period and was well tolerated.