HIV and fungal priority pathogens

The burden of invasive fungal infections associated with opportunistic fungal pathogens is a persistent challenge, particularly among people with advanced HIV disease. In October, 2022, WHO published the Fungal Priority Pathogens List (FPPL)-the first global effort to systematically prioritise funga...

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Published inThe lancet HIV Vol. 10; no. 11; p. e750
Main Authors Sati, Hatim, Alastruey-Izquierdo, Ana, Perfect, John, Govender, Nelesh P, Harrison, Tom S, Chiller, Tom, Sorrell, Tania C, Bongomin, Felix, Oladele, Rita, Chakrabarti, Arunaloke, Wahyuningsih, Retno, Colombo, Arnaldo Lopes, Rodriguez-Tudela, Juan Luis, Beyrer, Chris, Ford, Nathan
Format Journal Article
LanguageEnglish
Published Netherlands 01.11.2023
Subjects
Histoplasma
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
Humans
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Summary:The burden of invasive fungal infections associated with opportunistic fungal pathogens is a persistent challenge, particularly among people with advanced HIV disease. In October, 2022, WHO published the Fungal Priority Pathogens List (FPPL)-the first global effort to systematically prioritise fungal pathogens. Of the 19 pathogens in the WHO FPPL, four opportunistic pathogens in particular cause invasive diseases in people living with HIV: Cryptococcus neoformans, Histoplasma spp, Pneumocystis jirovecii, and Talaromyces marneffei. These four fungal pathogens are major causes of illness and death in people with advanced HIV and overwhelmingly affect those in low-income and middle-income countries. Access to diagnostics, improved surveillance, targeted support for innovation, and an enhanced public health focus on these diseases are needed in the effort to reduce HIV-associated deaths.
ISSN:2352-3018
DOI:10.1016/S2352-3018(23)00174-1