Combinatorial approaches to synthetic receptors

Combinatorial chemistry can be efficiently used for the synthesis and evaluation of binding properties of libraries of synthetic receptors. This approach has been applied particularly to ‘tweezer’ and other ‘multi-armed’ receptors, and has been used for the identification of receptors for peptides i...

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Bibliographic Details
Published inCurrent opinion in chemical biology Vol. 8; no. 3; pp. 305 - 310
Main Authors Srinivasan, Natarajan, Kilburn, Jeremy D
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2004
Subjects
Binding Sites
Biosensing Techniques
Chemistry, Pharmaceutical
Combinatorial Chemistry Techniques
Drug Design
Molecular Structure
Peptide Library
Peptides - chemistry
Peptides - metabolism
Receptors, Drug - analysis
Receptors, Drug - chemistry
Receptors, Drug - metabolism
MALDI
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Summary:Combinatorial chemistry can be efficiently used for the synthesis and evaluation of binding properties of libraries of synthetic receptors. This approach has been applied particularly to ‘tweezer’ and other ‘multi-armed’ receptors, and has been used for the identification of receptors for peptides in aqueous media, and for the development of new sensors and sensor arrays.
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ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2004.04.014