Serological Property of Perchloric Acid-Soluble Glycoprotein Fractions of Human Meconiums

Perchloric acid-soluble fractions (PASFs) were separated, in yields of 87.0-151.9 mg per 1.0 g of wet meconium sample, from six samples of human meconium, and identified as glycoproteins having 41.2-74.1% carbohydrate by chemical composition analysis. Six PASFs reacted with anti-A, -B, -Lea and -Leb...

Full description

Saved in:
Bibliographic Details
Published inYAKUGAKU ZASSHI Vol. 113; no. 7; pp. 532 - 536
Main Authors UCHIDE, Noboru, OHYAMA, Kunio, YAMAKAWA, Toshio, WATANABE, Hajime, HIRAKAWA, Shun, YONEYAMA, Kuniyoshi, OHKUMA, Seiichi
Format Journal Article
LanguageJapanese
English
Published The Pharmaceutical Society of Japan 1993
Subjects
human meconium
oncofetal substance
Vgu glycoprotein
Vicia graminea lectin
Vicia unijuga lectin
Online AccessGet full text

Cover

More Information
Summary:Perchloric acid-soluble fractions (PASFs) were separated, in yields of 87.0-151.9 mg per 1.0 g of wet meconium sample, from six samples of human meconium, and identified as glycoproteins having 41.2-74.1% carbohydrate by chemical composition analysis. Six PASFs reacted with anti-A, -B, -Lea and -Leb sera, but did not react with anti-M and -N sera. These PASFs alos reacted with many lectins such as DBA, UEA-I, Vicia graminea lectin (VGA), Vicia unijuga lectin (VUA), Con A, WGA, RCA-I, PHA-E, SBA, SJA, and influenza A and B viruses. The serological results show that six PASFs contained VGA or VUA-binding (Vgu) glycoproteins as new oncofetal substances, but did not contain M and N blood group substances.
ISSN:0031-6903
1347-5231
DOI:10.1248/yakushi1947.113.7_532