YES-10 Improves Stress, Tension, and Fatigue by Reducing Cortisol and IL-6 Levels

• Published in: Journal of medicinal food Vol. 25; no. 2; p. 205
• Main Authors: Noh, Yoo-Hun, Hong, Junkee, Lee, Ji-Won, Kim, Sung-Su, Kang, Il-Jun, Whang, Wan Kyunn, Myung, Soon-Chul, Chung, Myung-Hee, Won, Moo-Ho
• Format: Journal Article
• Language: English
• Published: United States 01.02.2022
• Subjects: Anxiety; Cytokines; Depression - drug therapy; Fatigue; Humans; Hydrocortisone; Interleukin-6; cortisol; stress; fatigue; depression; YES-10; tension relief
• ISSN: 1557-7600
• DOI: 10.1089/jmf.2021.K.0129

The extract of Rupr. (CMR) inhibits the production of proinflammatory mediators from lipopolysaccharide-stimulated peritoneal macrophages and concanavalin A-stimulated splenocytes. Pers. (EAP) extract suppresses the production of reactive oxygen species (ROS) from preadipocytes. Furthermore, the mixture of the leaf extracts of CMR and EAP, YES-10 , protected against nerve injuries induced by ischemia/reperfusion, suggesting a ROS-scavenging action. These observations show the anti-inflammatory action of YES-10. Inflammatory cytokines can cause alterations in mental function, including depression, by influencing the neurotransmitter system. Thus, it was hypothesized that YES-10 could improve mental health, such as depression, anxiety, and sense of well-being. Seventy-two subjects were recruited and randomly divided into YES-10 or placebo groups (  = 36 per group). Each group was daily administered two capsules orally, containing 200 mg of YES-10 or placebo, for 4 weeks in a double-blinded manner and tested for levels of depression, anxiety, well-being, and mental fitness using the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Psychosocial Well-being Index (PWI), and Mental Fitness Scale (MFS). In addition, the levels of cortisol (a stress hormone), interleukin-6 (IL-6) (an inflammatory cytokine), and 8-hydroxydeoxyguanosine (8-OHdG; a marker of oxidative stress) in the serum were measured. The BDI, BAI, PWI, and MFS scores decreased significantly, and the serum levels of cortisol, IL-6, and 8-OHdG were lowered significantly (  < .05), suggesting that YES-10 has the ability to improve mental health by relieving stress and by decreasing inflammation and oxidative stress.