An Innovative Bioceramic Bone Graft with Platelet-Rich Plasma for Rapid Bone Healing and Regeneration in a Rabbit Model

• Published in: Applied sciences Vol. 11; no. 11; p. 5271
• Main Authors: Syam, Syamsiah, Chang, Chun-Wei, Lan, Wen-Chien, Ou, Keng-Liang, Huang, Bai-Hung, Lin, Yu-Yeong, Saito, Takashi, Tsai, Hsin-Yu, Chuo, Yen-Chun, Yang, Tzu-Sen, Liu, Chung-Ming, Hou, Ping-Jen
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.06.2021
• Subjects: bioceramic bone graft; Bioceramics; Blood platelets; Bone density; Bone grafts; Bone growth; Bone healing; bone regeneration; Bones; Calcium sulfate; Calcium sulfate hemihydrate; Computed tomography; Defects; Grafting; Grafts; Growth factors; Healing; Implantation; Investigations; Maxillary sinus; Osteogenesis; Plasma; platelet-rich plasma; Rabbits; Regeneration; Skin & tissue grafts; Substitute bone; Surgeons; Surgery; Tissue engineering; Variance analysis; α-calcium sulfate hemihydrate; Belgium; United States > US
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app11115271

This study aimed to investigate the effect of combining an innovative bioceramic α-calcium sulfate hemihydrate (α-CSH, CaSO4⋅0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit’s artificially maxillary sinus defects: the right maxillary sinus received α-CSH, while α-CSH combine with PRP (α-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with α-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of α-CSH/PRP displays better bone healing and regeneration progress than α-CSH after 2 weeks implantation. Therefore, the innovative α-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.