The Effect of Sex and Age on Small Intestinal Transit Times in Humans

This study utilizes a novel approach of small bowel video capsule endoscopy for investigating the influence of sex and age on small intestinal transit times (SITT) in humans. A total of 81 outpatients undergoing investigations with the small bowel video capsule endoscope (SB-VCE) and meeting inclusi...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 105; no. 2; pp. 682 - 686
Main Authors Fischer, Monika, Fadda, Hala M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.2016
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Aging - physiology
bioavailability
Capsule Endoscopy - methods
controlled release
Female
gastrointestinal
Gastrointestinal Transit - physiology
Humans
ileum
Intestine, Small - physiology
jejunum
Male
Middle Aged
modified release
oral drug delivery
residence times
Retrospective Studies
Sex Characteristics
small intestine
Young Adult
gastrointestinal
ileum
controlled release
residence times
bioavailability
oral drug delivery
small intestine
jejunum
modified release
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Summary:This study utilizes a novel approach of small bowel video capsule endoscopy for investigating the influence of sex and age on small intestinal transit times (SITT) in humans. A total of 81 outpatients undergoing investigations with the small bowel video capsule endoscope (SB-VCE) and meeting inclusion criteria were included in this study. Following an overnight fast, patients swallowed the SB-VCE with a glass of water. SITT were calculated from the first duodenal image to the first cecal image. This study showed that the SB-VCE provides accurate and reliable measurements of SITT under real-life conditions. A large inter-individual variability in SITT was observed, with times ranging from 50 to 460 min. This variability can have implications on drug absorption and bioavailability. The median SITT were 219 min for females and 191 min for males. Although SITT were 28 min longer in females than males, this difference was not found to be statistically significant (p = 0.66). No correlation was found between age and SITT (Pearson correlation coefficient 0.19). Therefore, any drug bioavailability differences of modified release dosage preparations that are observed between adult patient groups of different age or sex are unlikely to be attributable to SITT.
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ISSN:0022-3549
1520-6017
DOI:10.1002/jps.24619