Leucine-rich repeat-containing G protein-coupled receptor 5 expression in lymph node metastases of colorectal cancer: Clinicopathological insights and prognostic implications

• Published in: Pathology international Vol. 74; no. 7; pp. 387 - 393
• Main Authors: Sawaguchi, Hiroshi, Uehara, Takeshi, Iwaya, Mai, Asaka, Shiho, Nakajima, Tomoyuki, Kamakura, Masato, Nagaya, Tadanobu, Yoshizawa, Takahiro, Ota, Hiroyoshi, Umemura, Takeji
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.07.2024; John Wiley and Sons Inc
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Female; Gene expression; Humans; Leucine; Lymph nodes; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Lymphatic system; Male; Metastases; Metastasis; Middle Aged; Necrosis; Original; Prognosis; Proteins; Receptors; Receptors, G-Protein-Coupled - genetics; Receptors, G-Protein-Coupled - metabolism; Stem cells; Surgical equipment; Tumor cells; Tumors; colorectal cancerl; RNA in situ hybridization; eucine‐rich repeat‐containing G‐protein‐coupled receptor 5; lymph node metastasis

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a significant cancer stem cell marker in colorectal cancer (CRC), lacks lymph node (LN) expression studies. In this study, we identified LGR5 expression by RNAscope, a highly sensitive RNA in situ method, and analyzed its associatio...