Improvement of sleep architecture in PD with subthalamic nucleus stimulation

High-frequency stimulation of the subthalamic nucleus (STN) was used to investigate the relationship of sleep disorders with motor handicap in PD. In 10 insomniac patients with PD, stimulation reduced nighttime akinesia by 60% and completely suppressed axial and early morning dystonia, but did not a...

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Bibliographic Details
Published inNeurology Vol. 55; no. 11; p. 1732
Main Authors Arnulf, I, Bejjani, B P, Garma, L, Bonnet, A M, Houeto, J L, Damier, P, Derenne, J P, Agid, Y
Format Journal Article
LanguageEnglish
Published United States 12.12.2000
Subjects
Adult
Electric Stimulation
Female
Humans
Male
Middle Aged
Parkinson Disease - physiopathology
Reaction Time - physiology
Sleep - physiology
Subthalamic Nucleus - physiopathology
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Summary:High-frequency stimulation of the subthalamic nucleus (STN) was used to investigate the relationship of sleep disorders with motor handicap in PD. In 10 insomniac patients with PD, stimulation reduced nighttime akinesia by 60% and completely suppressed axial and early morning dystonia, but did not alleviate periodic leg movements (n = 3) or REM sleep behavior disorders (n = 5). Total sleep time increased by 47%; wakefulness after sleep onset decreased by 51 minutes. Insomnia in patients with PD may predominantly result from nighttime motor disability.
ISSN:0028-3878
DOI:10.1212/WNL.55.11.1732