Symptomatic bone marrow metastasis in triple-negative breast cancer: a case report and literature review

Bone metastasis is common in breast cancer, but symptomatic bone marrow involvement is exceedingly rare. This report presents a case of a young female patient with triple-negative breast cancer (TNBC) initially presenting with symptomatic bone marrow metastasis. Upon admission, blood tests revealed...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in oncology Vol. 15; p. 1570355
Main Authors Zheng, Chenhui, Dai, Jingjing, Wang, Yu, Zheng, Danni, Lin, Renzhi, Zheng, Zhibao
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2025
Subjects
advanced breast cancer
case report
nutritional support
symptomatic bone marrow metastasis
thrombocytopenia
triple-negative breast cancer (TNBC)
symptomatic bone marrow metastasis
case report
nutritional support
triple-negative breast cancer (TNBC)
advanced breast cancer
thrombocytopenia
Online AccessGet full text

Cover

More Information
Summary:Bone metastasis is common in breast cancer, but symptomatic bone marrow involvement is exceedingly rare. This report presents a case of a young female patient with triple-negative breast cancer (TNBC) initially presenting with symptomatic bone marrow metastasis. Upon admission, blood tests revealed severe thrombocytopenia. Bone marrow biopsy confirmed tumor cell infiltration, and immunohistochemistry identified metastatic breast cancer cells. The patient received paclitaxel and eribulin chemotherapy combined with transfusion support, achieving significant symptom control. This rare case highlights the importance of early detection and aggressive management in TNBC with bone marrow metastasis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2025.1570355