A Broad Overview on Pituitary Adenylate Cyclase-Activating Polypeptide Role in the Eye: Focus on Its Repairing Effect in Cornea

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is a neuropeptide with widespread distribution throughout the central and peripheral nervous system as well as in many other peripheral organs. It plays cytoprotective effects mediated mainly through the activation of specific receptors. PAC...

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Bibliographic Details
Published inApplied sciences Vol. 12; no. 2; p. 760
Main Authors Maugeri, Grazia, D’Amico, Agata Grazia, D’Agata, Velia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.01.2022
Subjects
Cell cycle
Collagen
Cornea
Cytokeratin
Endothelium
eye
Homeostasis
Hydration
injury
Kinases
Nervous system
Organs
PACAP
Peripheral nervous system
Pituitary adenylate cyclase-activating polypeptide
Polypeptides
repair
Surgical outcomes
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Summary:Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is a neuropeptide with widespread distribution throughout the central and peripheral nervous system as well as in many other peripheral organs. It plays cytoprotective effects mediated mainly through the activation of specific receptors. PACAP is known to play pleiotropic effects on the eye, including the cornea, protecting it against different types of insult. This review firstly provides an overview of the anatomy of the cornea and summarizes data present in literature about PACAP’s role in the eye and, in particular, in the cornea, either in physiological or pathological conditions.
ISSN:2076-3417
2076-3417
DOI:10.3390/app12020760