Histological Evaluation of a New Beta-Tricalcium Phosphate/Hydroxyapatite/Poly (1-Lactide-Co-Caprolactone) Composite Biomaterial in the Inflammatory Process and Repair of Critical Bone Defects

Background: The use of biomaterials is commonplace in dentistry for bone regeneration. The aim of this study was to evaluate the performance of a new alloplastic material for bone repair in critical defects and to evaluate the extent of the inflammatory process. Methods: Forty-five New Zealand rabbi...

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Published inSymmetry (Basel) Vol. 11; no. 11; p. 1356
Main Authors Martinez, Elizabeth Ferreira, Rodrigues, Ana Elisa Amaro, Teixeira, Lucas Novaes, Esposito, Andrea Rodrigues, Cabrera, Walter Israel Rojas, Demasi, Ana Paula Dias, Passador-Santos, Fabricio
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2019
Subjects
alloplastic biomaterials
Animals
Biocompatibility
biomaterials
Biomedical materials
bone regeneration
Calcium phosphates
Defects
Dentistry
Hydroxyapatite
implantology
Inflammatory response
Mechanical properties
Microscopy
Performance evaluation
Polymers
Rabbits
Regeneration (physiology)
Repair
Germany
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Summary:Background: The use of biomaterials is commonplace in dentistry for bone regeneration. The aim of this study was to evaluate the performance of a new alloplastic material for bone repair in critical defects and to evaluate the extent of the inflammatory process. Methods: Forty-five New Zealand rabbits were divided into five groups according to evaluation time (7, 14, 30, 60, 120 days), totaling 180 sites with six-millimeter diameter defects in their tibiae. The defects were filled with alloplastic material consisting of poly (lactide-co-caprolactone), beta-tricalcium phosphate, hydroxyapatite and nano-hydroxyapatite (BTPHP) in three different presentations: paste, block, and membrane. Comparisons were established with reference materials, such as Bio-ossTM, Bio-oss CollagenTM, and Bio-gideTM, respectively. The samples were HE-stained and evaluated for inflammatory infiltrate (scored for intensity from 0 to 3) and the presence of newly formed bone at the periphery of the defects. Results: Greater bone formation was observed for the alloplastic material and equivalent inflammatory intensity for both materials, regardless of evaluation time. At 30 days, part of the synthetic biomaterial, regardless of the presentation, was resorbed. Conclusions: We concluded that this novel alloplastic material showed osteoconductive potential, biocompatibility, low inflammatory response, and gradual resorption, thus an alternative strategy for guided bone regeneration.
ISSN:2073-8994
2073-8994
DOI:10.3390/sym11111356