The use of fish cell cultures as an indication of contaminant toxicity to fish

The cytotoxicity of 12 chemicals to rainbow trout cells (RTG-2) was determined in culture. The indicator of cytotoxicity was the inability of cells to attach to a growth surface after chemical exposure. From most toxic to least toxic, these chemicals were pentachlorophenol, p-methylaminophenol, 2,4-...

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Bibliographic Details
Published inAquatic toxicology Vol. 6; no. 2; pp. 147 - 155
Main Authors Bols, N.C., Boliska, S.A., Dixon, D.G., Hodson, P.V., Kaiser, K.L.E.
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.01.1985
Elsevier Science
Subjects
Biological and medical sciences
cytotoxicity
Environmental pollutants toxicology
Freshwater
Medical sciences
phenols
QSARs
rainbow trout
RTG-2
Toxicology
Water
RTG-2
phenols
rainbow trout
QSARs
cytotoxicity
Water
Cell culture
Pollutant
Vertebrata
Investigation method
Toxicity
Pisces
Animal
Phenols
Cytotoxicity
Salmo gairdneri
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Summary:The cytotoxicity of 12 chemicals to rainbow trout cells (RTG-2) was determined in culture. The indicator of cytotoxicity was the inability of cells to attach to a growth surface after chemical exposure. From most toxic to least toxic, these chemicals were pentachlorophenol, p-methylaminophenol, 2,4-dichlorophenol, p-chlorophenol, p-cyanophenol, p-nitrophenol, benzene, p-methylphenol, aniline, phenol, p-methoxyphenol and 1,2,4-trichlorobenzene. The cytotoxicity of these compounds was found to be significantly correlated to their water-borne toxicity to rainbow trout.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0166-445X
1879-1514
DOI:10.1016/0166-445X(85)90013-X