Differential Effects of Morphine on Operant Escape Behavior and Averse Symptom Induced by Dorsal Central Gray Stimulation in Rats

The involvement of a central opiate mechanism in the operant escape behavior induced by dorsal central gray (DCG) stimulation was investigated in rats. Morphine (2-10 mg/kg, i.p.) produced a rise in the DCG-stimulation threshold, but did not suppress rapid running as an averse symptom. Naloxone alon...

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Bibliographic Details
Published inJapanese journal of pharmacology Vol. 55; no. 1; pp. 169 - 173
Main Authors Moriyama, Minehiro, Gomita, Yutaka, Ichimaru, Yasuyuki, Araki, Yasunori
Format Journal Article
LanguageEnglish
Published The Japanese Pharmacological Society 1991
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Summary:The involvement of a central opiate mechanism in the operant escape behavior induced by dorsal central gray (DCG) stimulation was investigated in rats. Morphine (2-10 mg/kg, i.p.) produced a rise in the DCG-stimulation threshold, but did not suppress rapid running as an averse symptom. Naloxone alone affected neither the threshold nor the averse symptom. Nevertheless, naloxone counteracted morphine-induced increments in the threshold. These results suggest that the opiate system may be indirectly involved in certain aspects of the operant escape behavior induced by the DCG-stimulation.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.55.169