Fe/Mn Multilayer Nanowires as High-Performance T1-T2 Dual Modal MRI Contrast Agents

• Published in: Materials Vol. 14; no. 9; p. 2238
• Main Authors: Cao, Xiaoming, Gu, Liyuan, Hu, Shike, Mukhtar, Aiman, Wu, Kaiming
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.04.2021; MDPI
• Subjects: Aluminum; CAs; Contrast agents; dual modal; Electrodes; Iron; Magnetic fields; Magnetic resonance imaging; Manganese; MRI; Multilayers; Nanomaterials; Nanoparticles; nanowire; Nanowires; relaxation; Beijing China; China; Japan; Germany
• ISSN: 1996-1944; 1996-1944
• DOI: 10.3390/ma14092238

A lot of nanomaterials are using T1-T2 dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T1-T2 dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T1-T2 dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r1 value (21.8 mM−1s−1) and r2 value (74.8 mM−1s−1) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM−1s−1) and Fe NW (59.3 mM−1s−1), respectively. We predict that our Fe/Mn multilayer NW could be used as T1-T2 dual mode MRI CAs in the near future.