Genomic analysis of the adenylate cyclase-hemolysin C-terminal region of Bordetella pertussis, Bordetella parapertussisand Bordetella bronchiseptica

Adenylate cyclase-hemolysin plays an important role in the virulence of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica species. Its C-terminal region carries protective epitopes and receptor binding site for human cells. Genomic analyses of this region indicate no polym...

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Bibliographic Details
Published inResearch in microbiology Vol. 160; no. 5; pp. 330 - 336
Main Authors Chenal-Francisque, Viviane, Caro, Valérie, Boursaux-Eude, Caroline, Guiso, Nicole
Format Journal Article
LanguageEnglish
Published Elsevier SAS 01.06.2009
Subjects
Adenylate cyclase-hemolysin
Bordetella
Bordetella bronchiseptica
Bordetella parapertussis
Bordetella pertussis
cyaA gene
cyaA gene
Adenylate cyclase-hemolysin
Bordetella
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Summary:Adenylate cyclase-hemolysin plays an important role in the virulence of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica species. Its C-terminal region carries protective epitopes and receptor binding site for human cells. Genomic analyses of this region indicate no polymorphism in B. pertussis and B. parapertussis regions, but substantial variability in B. bronchiseptica that might be linked to the various niches of this species.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2009.03.006