Para-bombay phenotype of a pregnant mother in Malaysia: Transfusion for an extremely premature baby

Para-Bombay blood phenotype is a rare blood group with limited cases reported worldwide. This blood group is characterized by the absence of ABH antigen on red blood cells but presence of ABH secretor substances in the body secretion. This rare phenotype is usually misinterpreted as O and may endang...

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Bibliographic Details
Published inOman medical journal Vol. 37; no. 1; pp. 1 - 4
Main Authors Pei, Tan Pei, Ahmad, Nor Hafizah, Noor, Noor Haslina Mohd
Format Journal Article
LanguageEnglish
Published Muscat, Oman Oman Medical Specialty Board 01.01.2022
OMJ
Subjects
ABO system
Blood
blood grouping
Blood groups
blood transfusion
Case Reports
delivery
Emergency medical services
Hospital care
malaysia
Planning
Premature infants
Prenatal care
Safety measures
Social aspects
Transfusion
Malaysia
Blood Transfusion
Delivery
Blood Grouping
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Summary:Para-Bombay blood phenotype is a rare blood group with limited cases reported worldwide. This blood group is characterized by the absence of ABH antigen on red blood cells but presence of ABH secretor substances in the body secretion. This rare phenotype is usually misinterpreted as O and may endanger the patient if urgent blood transfusion is required. A mother who was labelled as group O Rh D positive during antenatal followup was found to have ABO discrepancy during delivery. The newborn was admitted for extremely premature delivery at 25 weeks. As the baby required transfusion, problem arose during cross matching with the mother's sample. It was found that the mother was group O Rh D positive in forward grouping. However, the reverse grouping showed the presence of reaction (2+) in O cells. The baby was grouped as O Rh D positive. As transfusion was urgently needed due to baby's unstable condition, group O Rh D positive packed cell was found compatible with baby's serum, subsequently transfused. Bombay blood donor was contacted, and the donated blood was sent to the hospital for further management. Further investigations were performed, indicating that the mother is para- Bombay A. Due to recent transfusion to baby, we suggested to repeat baby's blood group after the baby is one year old. Para-Bombay was usually mislabelled as O if the sample was not tested with O cell in reverse grouping. Additional tests may be needed during antenatal follow-up to prevent complications during delivery, which requires emergency blood transfusion.
Bibliography:Oman Medical Journal, Vol. 37, No. 1, Jan 2022, [1]-[4]
Informit, Melbourne (Vic)
ISSN:1999-768X
2070-5204
DOI:10.5001/omj.2021.45