Comprehensive Phenotyping of Human PB NK Cells by Flow Cytometry

The NK cell compartment provides powerful innate defenses against virus‐infected and tumor cells. Specific NK cell receptors control this process and maintain the immune system homeostasis and prevent autoimmunity. A wide variety of NK cell subsets with different functional capabilities exist and th...

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Published inCytometry. Part A Vol. 97; no. 9; pp. 891 - 899
Main Authors Del Zotto, Genny, Antonini, Francesca, Pesce, Silvia, Moretta, Francesca, Moretta, Lorenzo, Marcenaro, Emanuela
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.09.2020
Wiley Subscription Services, Inc
Subjects
Autoimmunity
Flow cytometry
Homeostasis
human NK cells
Immune system
Microenvironments
Mushrooms
Natural killer cells
NK cell subsets
Peripheral blood
Phenotyping
Tumor cells
Viruses
human NK cells
flow cytometry
phenotyping
NK cell subsets
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Summary:The NK cell compartment provides powerful innate defenses against virus‐infected and tumor cells. Specific NK cell receptors control this process and maintain the immune system homeostasis and prevent autoimmunity. A wide variety of NK cell subsets with different functional capabilities exist and this reflects not only the different maturation stages of NK cells but also different microenvironments in which they can operate. In this review, we will give an overview on the various NK cell subsets present in peripheral blood of healthy donors in order to clearly and univocally identify them on the basis of their phenotypic traits using flow cytometry. © 2020 International Society for Advancement of Cytometry
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ISSN:1552-4922
1552-4930
1552-4930
DOI:10.1002/cyto.a.24001