Effects of Flutropium on Experimental Models of Drug- and Allergy-Induced Rhinitis in Guinea Pigs

• Published in: Japanese journal of pharmacology Vol. 55; no. 3; pp. 321 - 328
• Main Authors: Mizuno, Hiroyuki, Kawamura, Yutaka, Iwase, Nobuhisa, Ohno, Hiromitsu
• Format: Journal Article
• Language: English
• Published: The Japanese Pharmacological Society 1991
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1254/jjp.55.321

The effects of flutropium on histamine (Hist)-induced increase in intra nasal pressure in non-sensitized guinea pigs and nasal mucosa capillary permeability in passively sensitized guinea pigs were investigated. Flutropium (0.3%), atropine (0.3%), diphenhydramine (0.01%) and cimetidine (0.1%) were directly inhaled into the nasal cavities by an ultrasonic nebulizer for 20 min, followed by inhalation of Hist (0.1%) for 10 min. Flutropium, atropine and diphenhydramine had an inhibitory action on the Hist-induced increase in intranasal pressure in guinea pigs. Cimetidine had no effect on this system. In passively sensitized guinea pigs (the challenge was performed 48 hr after sensitization), a 0.1-1.0 mg/kg injection of flutropium (i.v.) dosedependently inhibited the allergic nasal mucosa capillary permeability. Atropine (10 mg/kg, i.v.) had no inhibitory action on this system. These results suggest that inhalation into the nasal cavities and i.v. injection of flutropium are effective in experimental models of drug and allergy-induced rhinitis of the guinea pig.