Y-SNP haplogroups related to the Yqh+ heteromorphism in the Mexican northwestern population

• Published in: Journal of genetics Vol. 91; no. 3; pp. 297 - 302
• Main Authors: ROMO-MARTÍNEZ, ENRIQUE JHONATAN, MARTÍNEZ-CORTÉS, GABRIELA, BARAJAS-TORRES, REYNA LUCÍA, RUBI-CASTELLANOS, RODRIGO, MAGAÑA-TORRES, MARÍA TERESA, RANGEL-VILLALOBOS, HÉCTOR, GONZÁLEZ-GARCÍA, JUAN RAMÓN
• Format: Journal Article
• Language: English
• Published: India Springer-Verlag 01.12.2012; Springer; Springer Nature B.V
• Subjects: ancestry; Animal Genetics and Genomics; Biomedical and Life Sciences; Chromosomes; Chromosomes, Human, Y - genetics; Evolutionary Biology; Gene Frequency; Genetics, Population - methods; Geography; Haplotypes - genetics; heterochromatin; Humans; Karyotype; Life Sciences; Male; males; Mexico; Microbial Genetics and Genomics; Morphology; Plant Genetics and Genomics; polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Population genetics; Research Article; single nucleotide polymorphism; Single nucleotide polymorphisms; Y chromosome; Mexico; haplogroups; ancestry; Y-chromosome single nucleotide polymorphisms; Yq12 heteromorphism
• ISSN: 0022-1333; 0973-7731
• DOI: 10.1007/s12041-012-0187-x

Morphological variation of the Y chromosome has been observed in different populations. This variation is mostly related to the heteromorphic Yq12 band, which is composed of a variable block of constitutive heterochromatin. The Yqh+ heteromorphism has a worldwide frequency of 2.85% and is considered clinically innocuous. The aim of this study was to identify the ancestry of the Yqh+ heteromorphism present in individuals from western Mexico. For this purpose, 17 Y-chromosome single nucleotide polymorphisms were analysed by multiplex polymerase chain reaction and SNaPshot assays. In 28 Yqh+ males, only five haplogroups were observed; with a haplogroup diversity of 0.4841 ± 0.1094, which was less than that observed in a study of unselected Mexican mestizo population. Differences were specifically conferred by the high frequencies of haplogroups R1b1 and P*(xQ,R), and by the absence of the Amerindian haplogroup Q (Q*(xQ1a3a) plus Q1a3a) from the Yqh+ group. This study suggests a post-1492 incorporation for Yqh+ chromosomes into the Mexican northwestern population.