Role of the P2 × 7 receptor in neurodegenerative diseases and its pharmacological properties

• Published in: Cell & bioscience Vol. 13; no. 1; p. 225
• Main Authors: Hu, Ziyan, Luo, Yifan, Zhu, Jinxi, Jiang, Danling, Luo, Zhenzhong, Wu, Lidong, Li, Jin, Peng, Shengliang, Hu, Jialing
• Format: Journal Article
• Language: English
• Published: England BioMed Central 13.12.2023; BMC
• Subjects: Amino acids; Antagonists; ATP; Binding sites; Cell death; Disease; Inflammation; Kinases; Ligands; Nervous system; Neurodegenerative Disease; Neurodegenerative diseases; P2 × 7R; Pharmacology; Phosphorylation; Proteins; Quality of life; Review; Structure-function relationships; Tumor necrosis factor-TNF; P2 × 7R; Neurodegenerative Disease; Antagonists; Pharmacology; ATP
• ISSN: 2045-3701; 2045-3701
• DOI: 10.1186/s13578-023-01161-w

Neurodegenerative diseases seriously affect patients' physical and mental health, reduce their quality of life, and impose a heavy burden on society. However, their treatment remains challenging. Therefore, exploring factors potentially related to the pathogenesis of neurodegenerative diseases and improving their diagnosis and treatment are urgently needed. Recent studies have shown that P2 × 7R plays a crucial role in regulating neurodegenerative diseases caused by neuroinflammation. P2 × 7R is an adenosine 5'-triphosphate ligand-gated cation channel receptor present in most tissues of the human body. An increase in P2 × 7R levels can affect the progression of neurodegenerative diseases, and the inhibition of P2 × 7R can alleviate neurodegenerative diseases. In this review, we comprehensively describe the biological characteristics (structure, distribution, and function) of this gene, focusing on its potential association with neurodegenerative diseases, and we discuss the pharmacological effects of drugs (P2 × 7R inhibitors) used to treat neurodegenerative diseases.