Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation

• Published in: Natural product research Vol. 29; no. 18; pp. 1761 - 1765
• Main Authors: Wang, Jun-Feng, Qin, Xiaochu, Xu, Fu-Quan, Zhang, Tianyu, Liao, Shengrong, Lin, Xiuping, Yang, Bin, Liu, Juan, Wang, Lishu, Tu, Zhengchao, Liu, Yonghong
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.09.2015
• Subjects: Animals; anti-inflammatory activity; Antitubercular Agents - chemistry; Antitubercular Agents - isolation & purification; antituberculosis activity; Cyclooxygenase Inhibitors - chemistry; Cyclooxygenase Inhibitors - isolation & purification; Fermentation; Fungi - chemistry; Inhibitory Concentration 50; marine fungus; Molecular Structure; Phakellia fusca Thiele; polyphenol; Polyphenols - chemistry; Polyphenols - isolation & purification; Porifera - microbiology; Pyrrolidinones - chemistry; Pyrrolidinones - isolation & purification; tetramic acid; antituberculosis activity; Phakellia fusca Thiele; marine fungus; polyphenol; anti-inflammatory activity; tetramic acid
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2014.999061

Fifteen compounds, including two tetramic acid derivatives, penicillenol A 1 (1) and penicillenol A 2 (2), six polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A-F (3-8), together with six phenolic bisabolane sesquiterpenoids (9-14) and diorcinol (15), were isolated from the fermentation broth of the marine-derived fungus ZSDS1-F11 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by using extensive NMR spectroscopic and mass spectrometric analyses. Compounds 3-5, 7 and 8 showed potent COX-1 inhibitory activity with IC 50 values of 5.3, 16.2, 30.2, 41.0 and 56.8 μM, respectively. Meanwhile, compounds 3-8 showed potent COX-2 inhibitory activity with IC 50 values of 3.1, 5.6, 3.0, 5.1, 3.2 and 3.7 μM, respectively. In addition, compound 1 exhibited antituberculosis activity with 96.1% inhibition at concentration of 10 μM.