Evaluation of antifungal activity of extracts of Piper regnellii obtained by supercritical fluid extraction

The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL...

Full description

Saved in:
Bibliographic Details
Published inNatural product research Vol. 27; no. 24; pp. 2355 - 2359
Main Authors Lemos, Caroline Ortega Terra, Svidzinsk, Terezinha Inez Estivalet, Baeza, Lilian Cristiane, Miranda, Nathielle, Nakamura, Celso Vataru, Cortez, Diógenes Aparício Garcia, Cardozo-Filho, Lúcio, Cabral, Vladimir Ferreira
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.12.2013
Subjects
antifungal activity
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Benzofurans - chemistry
Benzofurans - pharmacology
Chromatography, Supercritical Fluid - methods
extraction
Microbial Sensitivity Tests
neolignans
Phenols - chemistry
Phenols - pharmacology
Piper - chemistry
Piper regnellii
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
SC-CO
Trichophyton - drug effects
Online AccessGet full text

Cover

Abstract The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL against Trichophyton mentagrophytes. Neolignans eupomatenoid-3, eupomatenoid-5, eupomatenoid-6 and conocarpan were present in all extracts. The results indicate the possibility of further studies on the use of extracts of P. regnellii obtained by supercritical extraction, as potential sources of bioactive compounds for use in medicine.
AbstractList The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL against Trichophyton mentagrophytes. Neolignans eupomatenoid-3, eupomatenoid-5, eupomatenoid-6 and conocarpan were present in all extracts. The results indicate the possibility of further studies on the use of extracts of P. regnellii obtained by supercritical extraction, as potential sources of bioactive compounds for use in medicine.
The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL against Trichophyton mentagrophytes. Neolignans eupomatenoid-3, eupomatenoid-5, eupomatenoid-6 and conocarpan were present in all extracts. The results indicate the possibility of further studies on the use of extracts of P. regnellii obtained by supercritical extraction, as potential sources of bioactive compounds for use in medicine.
Author Nakamura, Celso Vataru
Cabral, Vladimir Ferreira
Svidzinsk, Terezinha Inez Estivalet
Miranda, Nathielle
Lemos, Caroline Ortega Terra
Cortez, Diógenes Aparício Garcia
Cardozo-Filho, Lúcio
Baeza, Lilian Cristiane
Author_xml – sequence: 1
  givenname: Caroline Ortega Terra
  surname: Lemos
  fullname: Lemos, Caroline Ortega Terra
  organization: Programa de Pós-graduação em Engenharia Química, Universidade Estadual de Maringá
– sequence: 2
  givenname: Terezinha Inez Estivalet
  surname: Svidzinsk
  fullname: Svidzinsk, Terezinha Inez Estivalet
  organization: Departamento de Análises Clínicas, Universidade Estadual de Maringá
– sequence: 3
  givenname: Lilian Cristiane
  surname: Baeza
  fullname: Baeza, Lilian Cristiane
  organization: Departamento de Análises Clínicas, Universidade Estadual de Maringá
– sequence: 4
  givenname: Nathielle
  surname: Miranda
  fullname: Miranda, Nathielle
  organization: Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá
– sequence: 5
  givenname: Celso Vataru
  surname: Nakamura
  fullname: Nakamura, Celso Vataru
  organization: Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá
– sequence: 6
  givenname: Diógenes Aparício Garcia
  surname: Cortez
  fullname: Cortez, Diógenes Aparício Garcia
  organization: Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá
– sequence: 7
  givenname: Lúcio
  surname: Cardozo-Filho
  fullname: Cardozo-Filho, Lúcio
  email: cardozo@deq.uem.br
  organization: Programa de Pós-graduação em Engenharia Química, Universidade Estadual de Maringá
– sequence: 8
  givenname: Vladimir Ferreira
  surname: Cabral
  fullname: Cabral, Vladimir Ferreira
  organization: Programa de Pós-graduação em Engenharia Química, Universidade Estadual de Maringá
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24007562$$D View this record in MEDLINE/PubMed
BookMark eNp9kE1P4zAQhi3EigK7_2CFcuTS4nEcNzkhhPiSkNjD7tma-KPyktrFdoD-exyVcsQXz4yfd17rPSGHPnhDyG-gC6AtvQC-bAWHbsEo1Iu2pgyaA3I8jeeCs-XhVw3djJyk9J9OSNMckRnjlC4bwY7J880rDiNmF3wVbIU-Ozv6FQ4VquxeXd5OY_OeY-nTVP9xGxOraFbeDINzVegzOm901W-rNJY3FV12qmyww-j0XlsMfpIfFodkfn3ep-Tf7c3f6_v549Pdw_XV41zVos5z23ZcC9shgFDQshpVA33NFPSlA22s6LUW5VDWWW5RA8NWYUebVhht6lNyvtu7ieFlNCnLtUuq_Ba9CWOSwEUheQPLgvIdqmJIKRorN9GtMW4lUDnFLPcxyylmuYu5yM4-HcZ-bfSXaJ9rAS53gPM2xDW-hThomXE7hGgjeuWSrL-1-AB0XY_b
CitedBy_id crossref_primary_10_1080_14786419_2015_1089243
crossref_primary_10_1080_14786419_2017_1361952
crossref_primary_10_2174_1385272824999200608133542
crossref_primary_10_1007_s13765_016_0178_3
Cites_doi 10.1021/np960036y
10.1007/s11947-009-0263-2
10.1016/S0031-9422(99)00177-6
10.1590/S0102-695X2005000400020
10.1016/B978-0-12-013320-8.50007-1
10.1016/j.jep.2008.01.039
10.1590/S0103-50532005000700007
ContentType Journal Article
Copyright 2013 Taylor & Francis 2013
Copyright_xml – notice: 2013 Taylor & Francis 2013
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1080/14786419.2013.830215
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 1478-6427
EndPage 2359
ExternalDocumentID 10_1080_14786419_2013_830215
24007562
830215
Genre Short Communication
Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
.7F
.QJ
0BK
0R~
29M
30N
36B
4.4
53G
5VS
AAAVI
AAENE
AAJMT
AALDU
AAMIU
AAPUL
AAQRR
ABBKH
ABCCY
ABFIM
ABHAV
ABJVF
ABLIJ
ABPEM
ABQHQ
ABTAI
ABXUL
ACGEJ
ACGFS
ACIWK
ACPRK
ACTIO
ADCVX
ADGTB
ADXPE
AEGYZ
AEISY
AENEX
AEOZL
AFKVX
AFOLD
AFRAH
AFWLO
AGDLA
AGMYJ
AHDLD
AIJEM
AIRXU
AJWEG
AKBVH
AKOOK
ALMA_UNASSIGNED_HOLDINGS
ALQZU
AQRUH
AVBZW
AWYRJ
BLEHA
CCCUG
CE4
CS3
DGEBU
DKSSO
DU5
EBD
EBS
EJD
EMB
EMOBN
E~A
E~B
F5P
FUNRP
FVPDL
GTTXZ
H13
HF~
HZ~
H~P
J.P
KYCEM
M4Z
MK0
NA5
NW0
O9-
RIG
RNANH
ROSJB
RTWRZ
S-T
SNACF
SV3
TCY
TFL
TFT
TFW
TTHFI
TWF
UT5
UU3
V1K
ZGOLN
~S~
AAAJW
AAHBH
ABKVM
ABPAQ
ABXYU
ABZMO
ACYAP
ADOGB
AFFNX
AFWJF
AHDZW
BDVFT
BKMSO
CAG
CGR
COF
CUY
CVF
CXCUG
ECM
EIF
LJTGL
NPM
OEUFU
TBQAZ
TUROJ
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c363t-f894d6f9a116c1823ac51b32c1b1821def6bdd6666029f4fad12a8ca90586ede3
ISSN 1478-6419
IngestDate Sat Oct 26 01:44:12 EDT 2024
Fri Aug 23 03:19:43 EDT 2024
Tue Oct 15 23:48:23 EDT 2024
Tue Jun 13 19:57:29 EDT 2023
IsPeerReviewed true
IsScholarly true
Issue 24
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c363t-f894d6f9a116c1823ac51b32c1b1821def6bdd6666029f4fad12a8ca90586ede3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMID 24007562
PQID 1465864517
PQPubID 23479
PageCount 5
ParticipantIDs proquest_miscellaneous_1465864517
informaworld_taylorfrancis_310_1080_14786419_2013_830215
crossref_primary_10_1080_14786419_2013_830215
pubmed_primary_24007562
PublicationCentury 2000
PublicationDate 2013-12-01
PublicationDateYYYYMMDD 2013-12-01
PublicationDate_xml – month: 12
  year: 2013
  text: 2013-12-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Natural product research
PublicationTitleAlternate Nat Prod Res
PublicationYear 2013
Publisher Taylor & Francis
Publisher_xml – name: Taylor & Francis
References cit0011
cit0001
cit0010
Falcao HS (cit0005) 2005; 15
cit0009
cit0006
cit0007
cit0002
References_xml – ident: cit0002
  doi: 10.1021/np960036y
– ident: cit0010
  doi: 10.1007/s11947-009-0263-2
– ident: cit0009
– ident: cit0001
  doi: 10.1016/S0031-9422(99)00177-6
– volume: 15
  start-page: 381
  year: 2005
  ident: cit0005
  publication-title: Braz J Pharmacogn.
  doi: 10.1590/S0102-695X2005000400020
  contributor:
    fullname: Falcao HS
– ident: cit0006
  doi: 10.1016/B978-0-12-013320-8.50007-1
– ident: cit0007
  doi: 10.1016/j.jep.2008.01.039
– ident: cit0011
  doi: 10.1590/S0103-50532005000700007
SSID ssj0021555
Score 2.0489469
Snippet The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most...
SourceID proquest
crossref
pubmed
informaworld
SourceType Aggregation Database
Index Database
Publisher
StartPage 2355
SubjectTerms antifungal activity
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Benzofurans - chemistry
Benzofurans - pharmacology
Chromatography, Supercritical Fluid - methods
extraction
Microbial Sensitivity Tests
neolignans
Phenols - chemistry
Phenols - pharmacology
Piper - chemistry
Piper regnellii
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
SC-CO
Trichophyton - drug effects
Title Evaluation of antifungal activity of extracts of Piper regnellii obtained by supercritical fluid extraction
URI https://www.tandfonline.com/doi/abs/10.1080/14786419.2013.830215
https://www.ncbi.nlm.nih.gov/pubmed/24007562
https://search.proquest.com/docview/1465864517
Volume 27
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Jj9MwFLbKzAEuiJ2yyUjcogx1nPU4lI4qVDoHWlFxiezYZiKGtkoTJPpb-LE8x3GSSgUNXKLYla3I7-vb_BaE3mip4o9E4IbcBwOFetxlnEUu90DZ95XyTDGdj_NwuvQ_rILVYPCrF7VUlfws2x_NK_kfqsIc0FVnyf4DZdtNYQLegb7wBArD80Y0nrSluuvrfB33A_9dnf2fNU0hYBq4r86EMtFu-VYWTiHr3sV57my49gwYJXRXwW-Z7Xygrqtc2LWWdo0SO2emWMfWVIt1moJBrWN5Jr-b4L2x6QkkncuilF-Zs5BF0YqBTz9ysdd9s2vIyELC4IoBw5J7Z7LTXdeuu-Tsd0zumfEh1H6ZccObusjdvNA-ESMwyqtc30f0PRqE9qJDpOHCPpi2YBhFfTbdjAwcPb_PdKmp9NsIcBgmR4WDiabUm4c-0UlKhJ7p8mck6IShDQCYX6YXy9ksXUxWi1vo1AM2Bvzz9Hz6_svn1qAHXSyw6Zjx6O2xnQ_UnYNiuH82aWrVZnEP3W1sEnxuAHYfDeT6Abo9tq0AH6JvHdDwRuEOaNgCTU9boOn3Gmi4BRq2QMP8Jz4AGq6BhjugPULLi8liPHWbLh1uRkNauipOfBGqhBESZmCtUpYFhFMvIxxGREgVciHASg5HXqJ8xQTxWJyxZBTEoRSSPkYn681aPkVYBlEWRyBhhK61T8MkkVR5ARcsSSJB2RC59jDTrSnGkpKmxq09_FQffmoOf4ji_omnZe0EU6ZjTUr_vvS1pU4Kh61v0QDTm2qnbWX4cD8g0RA9MWRrP0YHZEdgUTy7wern6E4H_hfopCwq-RIU3JK_anD2G1xVq-k
link.rule.ids 315,783,787,27936,27937,60214,61003
linkProvider Library Specific Holdings
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDI4QHODC-zGeQeLasTRp2h4RAo3XxAEkblXSJNIE2tDWHuDXYzfNBEhwgFvbyE3iuI6d2p8JOcFdRfRMEkktwEHhsY6UVmmkYzD2hXOxB9O5G8j-o7h-SkI04bQNq0Qf2nmgiEZX48eNh9EhJO6UiTSTgmGeCeNdRLDCNPMFifhfmMXRG8x8LtgukybBCJwlJAnZcz-85cvu9AW79GcLtNmJLleIDnPwASjP3brS3fL9G7zjvya5SpZbO5WeecFaI3N2tE4Wz0N5uA3yfDHDCadjRxUGHYHiABpMlcCKFPgYVD-mYU3x-n74aid0YpvCycMhHWs8lrCG6jc6raGtbMsuUPdSD02ghQ42yePlxcN5P2orN0Qll7yKXJYLI12uGJMleDBclQnTPC6ZhjtmrJPaGPCcYMlyJ5wyLFZZqfJekklrLN8i86PxyO4QapO0zFLQOgbx17nMc8tdnGij8jw1XHVIFFasePUAHQVrcU8DCwtkYeFZ2CHZ52UtquZgxPkqJgX_nfQ4iEABzMY_K2pkx_UU_ScYuEhY2iHbXjZmg8Eg3RSszN2_d3xEFvsPd7fF7dXgZo8sYYuPqNkn89WktgdgF1X6sJH8DzDJAPw
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT8MwDI4QSMCF92M8g8S1o2nStD0iYOI5cQCJW5U0iTQNbdPWHuDXYzfrBEhwgFvbyE3iuI6d2p8JOcVdRYQmDqQW4KDwSAdKqyTQERj7wrnIg-k8dOX1s7h9iV8-ZfFjWCX60M4DRdS6Gj_ukXFNRNwZE0kqBcM0E8bbCGCFWeYLYAiEKOk87M5cLtgt4zq_CHwlJGmS5354y5fN6Qt06c8GaL0RdVaJaqbg40_67arU7eL9G7rjf-a4RlamVio992K1TubsYIMsXTTF4TZJ_2qGEk6HjioMOQK1ATSYKIH1KPAxKH5Mwprg9WNvZMd0bOuyyb0eHWo8lLCG6jc6qaCtmBZdoO616pmGFjrYIs-dq6eL62BatyEouORl4NJMGOkyxZgswH_hqoiZ5lHBNNwxY53UxoDfJMMoc8IpwyKVFioL41RaY_k2mR8MB3aXUBsnRZqAzjGIvs5lllnuolgblWWJ4apFgmbB8pGH58jZFPW0YWGOLMw9C1sk_byqeVkfizhfwyTnv5OeNBKQA7Pxv4oa2GE1Qe8JBi5ilrTIjheN2WAwRDcBG3Pv7x0fk8XHy05-f9O92yfL2ODDaQ7IfDmu7CEYRaU-quX-AyCI_5o
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Evaluation+of+antifungal+activity+of+extracts+of+Piper+regnellii+obtained+by+supercritical+fluid+extraction&rft.jtitle=Natural+product+research&rft.au=Lemos%2C+Caroline+Ortega+Terra&rft.au=Svidzinsk%2C+Terezinha+Inez+Estivalet&rft.au=Baeza%2C+Lilian+Cristiane&rft.au=Miranda%2C+Nathielle&rft.date=2013-12-01&rft.eissn=1478-6427&rft.volume=27&rft.issue=24&rft.spage=2355&rft.epage=2359&rft_id=info:doi/10.1080%2F14786419.2013.830215&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1478-6419&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1478-6419&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1478-6419&client=summon