Evaluation of antifungal activity of extracts of Piper regnellii obtained by supercritical fluid extraction

• Published in: Natural product research Vol. 27; no. 24; pp. 2355 - 2359
• Main Authors: Lemos, Caroline Ortega Terra, Svidzinsk, Terezinha Inez Estivalet, Baeza, Lilian Cristiane, Miranda, Nathielle, Nakamura, Celso Vataru, Cortez, Diógenes Aparício Garcia, Cardozo-Filho, Lúcio, Cabral, Vladimir Ferreira
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2013
• Subjects: antifungal activity; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Benzofurans - chemistry; Benzofurans - pharmacology; Chromatography, Supercritical Fluid - methods; extraction; Microbial Sensitivity Tests; neolignans; Phenols - chemistry; Phenols - pharmacology; Piper - chemistry; Piper regnellii; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; SC-CO; Trichophyton - drug effects
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2013.830215

The antifungal activity of extracts obtained from Piper regnellii with supercritical carbon dioxide was tested against yeast and filamentous fungi. The most active extract was obtained from leaves extracts of P. regnellii at 40°C and 25 MPa, featuring a minimal inhibitory concentration of 3.9 μg/mL against Trichophyton mentagrophytes. Neolignans eupomatenoid-3, eupomatenoid-5, eupomatenoid-6 and conocarpan were present in all extracts. The results indicate the possibility of further studies on the use of extracts of P. regnellii obtained by supercritical extraction, as potential sources of bioactive compounds for use in medicine.