Synthesis and application of pentafluorosulfanylation reagents and derived aliphatic SF5-containing building blocks

Among the perfluorinated substituents of organic compounds, the pentafluorosulfanyl (SF5) group received remarkable attention in the past few decades due to its particular properties such as high thermal, chemical and metabolic stability, high density, high group electronegativity, high lipophilicit...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron Vol. 109; p. 132656
Main Author Haufe, Günter
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 12.03.2022
Subjects
Alkynes and carbonyls
Pentafluorosulfanylation
Radical addition reactions
SF5 alkenes
SF5-substituted building blocks
Sulfur hexafluoride
Alkynes and carbonyls
Radical addition reactions
SF5-substituted building blocks
Pentafluorosulfanylation
Sulfur hexafluoride
SF5 alkenes
Online AccessGet full text

Cover

More Information
Summary:Among the perfluorinated substituents of organic compounds, the pentafluorosulfanyl (SF5) group received remarkable attention in the past few decades due to its particular properties such as high thermal, chemical and metabolic stability, high density, high group electronegativity, high lipophilicity, and interesting effects on the biological activity of relevant compounds. This review retraces the massive progress made towards the preparation and application of reagents like SF5X (X = F, Cl, Br) for the synthesis of SF5-containing small building blocks designed for the construction of complex aliphatic molecules potentially applicable in drug and pesticide design as well as in materials sciences. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2022.132656