Does dexamethasone inhibit the growth of human gliomas?

Dexamethasone (10-(4)M) was shown to inhibit the growth of human gliomas in culture. This was indicated by the inhibition of incorporation of radioactively labeled thymidine into the deoxyribonucleic acid (DNA) of the cells, and by the increase in the generation time of cells exposed to the drug in...

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Bibliographic Details
Published inJournal of neurosurgery Vol. 47; no. 6; p. 864
Main Authors Sherbet, G V, Lakshmi, M S, Haddad, S K
Format Journal Article
LanguageEnglish
Published United States 01.12.1977
Subjects
Astrocytoma - drug therapy
Astrocytoma - metabolism
Brain Neoplasms - drug therapy
Brain Neoplasms - metabolism
Cell Division - drug effects
Cells, Cultured
Depression, Chemical
Dexamethasone - pharmacology
Dexamethasone - therapeutic use
DNA, Neoplasm - biosynthesis
Drug Evaluation
Humans
RNA, Neoplasm - biosynthesis
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Summary:Dexamethasone (10-(4)M) was shown to inhibit the growth of human gliomas in culture. This was indicated by the inhibition of incorporation of radioactively labeled thymidine into the deoxyribonucleic acid (DNA) of the cells, and by the increase in the generation time of cells exposed to the drug in vitro. On the other hand, tumors obtained from patients who had received dexamethasone before craniotomy grew considerably faster in vitro than tumors from patients who had not been given the drug before operation.
ISSN:0022-3085
DOI:10.3171/jns.1977.47.6.0864