Sulfa drug analogs: new classes of N-sulfonyl aminated azines and their biological and preclinical importance in medicinal chemistry (2000–2018)

• Published in: Medicinal chemistry research Vol. 28; no. 8; pp. 1099 - 1131
• Main Authors: Elgemeie, Galal H., Azzam, Rasha A., Elsayed, Rasha E.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2019; Springer Nature B.V
• Subjects: Anticancer properties; Antihypertensives; Azines; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Diuretics; Epilepsy; Inflammation; Mental disorders; Neurological diseases; Organic chemistry; Pharmacology/Toxicology; Review Article; Schizophrenia; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors; sulfonyl aminated azines; Medicinal chemistry; sulfonyl aminated pyrimidines; Sulfa drug analogs; sulfonyl aminated pyridines
• ISSN: 1054-2523; 1554-8120
• DOI: 10.1007/s00044-019-02378-6

N -sulfonylamino azinones has attracted the interest of numerous researchers and extensive investigations on their biological activities have been done. The present review provides an overview of the patents and reports filed during the last few years pertaining to the synthesis N -sulfonyl azinones as well as their biological and preclinical studies. A brief discussion on the significant biological findings is also provided. It has been established that N -sulfonylamino azinones is privileged heterocycles possessing diuretic, antihypertensive, anti-inflammatory, and anticancer and other biological activities. In particular, a new generation of competitive AMPA receptor antagonist based on N -sulfonylamino 1 H -quinazoline-2,4-diones is promising useful in the treatment neurological disorders such as epilepsy and schizophrenia. The scope of these new advances has been also highlighted in this review.