Coat/Tether Interactions-Exception or Rule?

Coat complexes are important for cargo selection and vesicle formation. Recent evidence suggests that they may also be involved in vesicle targeting. Tethering factors, which form an initial bridge between vesicles and the target membrane, may bind to coat complexes. In this review, we ask whether t...

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Published inFrontiers in cell and developmental biology Vol. 4; p. 44
Main Authors Schroeter, Saskia, Beckmann, Sabrina, Schmitt, Hans Dieter
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 17.05.2016
Subjects
Cell and Developmental Biology
coat complexes
tethering complex
protocoatomer
coated vesicles
vesicle trafficking
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Summary:Coat complexes are important for cargo selection and vesicle formation. Recent evidence suggests that they may also be involved in vesicle targeting. Tethering factors, which form an initial bridge between vesicles and the target membrane, may bind to coat complexes. In this review, we ask whether these coat/tether interactions share some common mechanisms, or whether they are special adaptations to the needs of very specific transport steps. We compare recent findings in two multisubunit tethering complexes, the Dsl1 complex and the HOPS complex, and put them into context with the TRAPP I complex as a prominent example for coat/tether interactions. We explore where coat/tether interactions are found, compare their function and structure, and comment on a possible evolution from a common ancestor of coats and tethers.
Bibliography:Edited by: Anne Spang, Biozentrum, University of Basel, Switzerland
Reviewed by: Benjamin S. Glick, University of Chicago, USA; Frederick Hughson, Princeton University, USA
This article was submitted to Membrane Traffic, a section of the journal Frontiers in Cell and Developmental Biology
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2016.00044