Factors Influencing Long-Term Local Recurrence, Distant Metastasis, and Survival in Patients with Soft Tissue Sarcoma of the Extremities Treated with Radiotherapy

• Published in: Cancers Vol. 16; no. 10; p. 1789
• Main Authors: Lebas, Arthur, Le Fevre, Clara, Waissi, Waisse, Chambrelant, Isabelle, Brinkert, David, Noel, Georges
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.05.2024
• Subjects: Care and treatment; Clinical outcomes; Complications and side effects; Diseases; Limbs; Liposarcoma; Medical prognosis; Metastases; Metastasis; Multivariate analysis; Patient outcomes; Patients; Radiation therapy; Radiotherapy; Relapse; Sarcoma; Soft tissue sarcoma; Stem cells; Surgery; Tumors; France; radiotherapy; prognostic factors; complications; limb sparing surgery; soft tissue sarcoma of the extremities
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16101789

Introduction: The prognostic factors for extremity soft-tissue sarcomas (ESTSs) treated with multimodal surgery and radiotherapy (RT) remain a subject of debate across diverse and heterogeneous studies. Methods: We retrospectively analyzed nonmetastatic ESTS patients treated with RT between 2007 and 2020 in Strasbourg, France. We assessed local control (LC), distant control (DC), overall survival (OS), and complications. Results: A total of 169 patients diagnosed with localized ESTS were included. The median age was 64 years (range 21–94 years). ESTS primarily occurred proximally (74.6%) and in the lower limbs (71%). Most tumors were grade 2–3 (71.1%), deep-seated (86.4%), and had R0 margins (63.9%). Most patients were treated with helical tomotherapy (79.3%). The median biologically effective dose (BED) prescribed was 75 BEDGy4 (range 45.0–109.9). The median follow-up was 5.5 years. The 5- and 10-year LC, DC, and OS rates were 91.7%, 76.8%, and 83.8% and 84.2%, 74.1%, and 77.6%, respectively. According to the univariate analysis, LC was worse for patients who received less than 75 BEDGy4 (p = 0.015). Deep tumors were associated with worse OS (p < 0.05), and grade 2–3 and undifferentiated pleomorphic sarcoma (UPS) were linked to both shorter DC and shorter OS (p < 0.05). IMRT was associated with longer LC than 3DRT (p = 0.018). Multivariate analysis revealed that patients with liposarcoma had better OS (p < 0.05) and that patients with distant relapse had shorter OS (p < 0.0001). Conclusion: RT associated with surgical resection was well tolerated and was associated with excellent long-term rates of LC, DC, and OS. Compared with 3DRT, IMRT improved local control. Liposarcoma was a favorable prognostic factor for OS. Intermediate- and high-grade tumors and deep tumors were associated with lower DC and OS.