Multifunctional bacterial imaging and therapy systems

Bacterial infections have severely affected human health, leading to a considerable number of human deaths. Inevitably direct and indirect contacts with medical devices, food packing and daily supplies with harmful bacteria are among the major transmission routes of bacterial infections. Effective b...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 6; no. 32; pp. 5198 - 5214
Main Authors Chen, Shuai, Li, Qiaoying, Wang, Xin, Yang, Ying-Wei, Gao, Hui
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 28.08.2018
Subjects
Ammonium
Antibacterial materials
Bacteria
Bacterial infections
Diagnostic systems
Drug resistance
Infections
Medical devices
Medical electronics
Medical equipment
Medical imaging
Nanoparticles
Polymers
Precision medicine
System effectiveness
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Summary:Bacterial infections have severely affected human health, leading to a considerable number of human deaths. Inevitably direct and indirect contacts with medical devices, food packing and daily supplies with harmful bacteria are among the major transmission routes of bacterial infections. Effective bacterial theranostic systems that combine diagnostic functions and therapeutic effects have received extensive attention due to their excellent features including high efficiency, real-time performance and low drug resistance. In this review article, we summarize the recent advances of antibacterial materials including natural antibacterial compounds, quaternary ammonium polymers, and inorganic or hybrid nanoparticles with the dual functions of detection and imaging. In particular, multiple imaging modalities and antibacterial modalities are systematically discussed in order to provide a better understanding of modern theranostics. Advanced antibacterial materials are classified and introduced, and their applications in multimodal imaging and therapy are reviewed.
Bibliography:Xin Wang was born in Shanxi Province, China, in 1992. She obtained her BSc degree in Chemistry in 2015 and MSc degree in Chemistry in 2018, both at Jilin University, under the supervision of Professor Ying-Wei Yang. Her research focuses on synthetic supramolecular macrocycles, pillararene-based organic-inorganic hybrid materials, and targeted and controlled drug delivery.
Hui Gao obtained her PhD in Chemistry from Nankai University (2005). After three years of post-doctoral research at the University of Montreal in Canada, she became an Associate Professor and now Full Professor in Tianjin University of Technology. She obtained an Invitation Fellowship (JSPS) for Research in Japan in 2012 and worked in Prof. Kazunori Kataoka's lab in the University of Tokyo for 10 months. Her main interests are the synthesis and assembly properties of polymers, drug delivery, as well as supramolecular chemistry.
Ying-Wei Yang received his degrees (BSc in 2000, PhD in 2005) from Nankai University, and gained postdoctoral training at ASU (with John Chaput), UCLA (with Sir Fraser Stoddart), and UCI (with Zhibin Guan) from 2005 to 2010. He became an Associate Professor of Chemistry at Jilin University in 2011 and was promoted to Full Professor in 2014. He has published over 140 scientific papers. His research centers on organic supramolecular chemistry and materials. He was named one of the world's most Highly Cited Researchers for 2017 by Clarivate Analytics, and one of the 2017 Chinese Most Cited Researchers by Elsevier.
Shuai Chen was born in Jiangsu Province, China, in 1993. He obtained his BE in Pharmaceutical Engineering from Tianjin University of Technology in 2016. Currently, he is an M. M. student and performs research under the direction of Professor Hui Gao at the same university. He is engaged in the field of antibacterial materials.
Qiaoying Li was born in Shandong Province, China, in 1991. She obtained her BSc degree in Pharmacy from Tianjin University of Technology in 2013. Later she joined Professor Gao's group in Pharmaceutical Chemistry at the same university. Her research focuses on the development of new materials for antibacterial applications.
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ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb01519h