Preparation of β-Cyclodextrin Conjugated, Gelatin Stabilized SBA 15-CuInS2/ZnS Quantum Dot Nanocomposites for Camptothecin Release

Camptothecin (CPT) is a potential anticancer drug. However, it faces challenges due to its poor water solubility and the need for an efficient drug release system. Herein, we developed a novel system composed of gelatin stabilized, mesoporous silica SBA15 encapsulated CuInS 2 /ZnS (CIS/ZnS) quantum...

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Published inJournal of inorganic and organometallic polymers and materials Vol. 34; no. 1; pp. 93 - 99
Main Authors Rajendran, Jose Varghese, Parani, Sundararajan, Remya, Vasudevan Pillay R., Lebepe, Thabang C., Maluleke, Rodney, Aladesuyi, Olanrewaju A., Thomas, Sabu, Oluwafemi, Oluwatobi Samuel
Format Journal Article
LanguageEnglish
Published New York Springer US 2024
Springer Nature B.V
Subjects
Chemistry
Chemistry and Materials Science
Conjugation
Cyclodextrins
Drug carriers
Emission analysis
Encapsulation
Fourier transforms
Gelatin
Infrared analysis
Inorganic Chemistry
Nanocomposites
Optical properties
Organic Chemistry
Polymer Sciences
Quantum dots
Zinc sulfide
Drug delivery
Quantum dots
Mesoporous silica
Photostability
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Summary:Camptothecin (CPT) is a potential anticancer drug. However, it faces challenges due to its poor water solubility and the need for an efficient drug release system. Herein, we developed a novel system composed of gelatin stabilized, mesoporous silica SBA15 encapsulated CuInS 2 /ZnS (CIS/ZnS) quantum dots (QDs) conjugated with β-cyclodextrin (β-CDs) for its potential use in the release of CPT. In this multifunctional system, β-CDs served as the drug carrier, SBA15 encapsulated QDs is capable of imaging and the gelatin was used to enhance the carrier-drug interaction. Fourier transform infrared (FTIR) analysis confirmed the successful conjugation of β-CDs to the Gel-SBA15 CIS/ZnS QDs, while optical analyses revealed excellent emission properties and high photostability. The β-CD-conjugated Gel-SBA15-CIS/ZnS QD nanocomposite was used to obtain the soluble derivate of CPT which further demonstrated a drug release profile following the triphasic model. Overall, the improved photostability and acceptable drug release profile of the β-CD conjugated Gel-SBA15-CIS/ZnS QD nanocomposite hold great promise for both imaging and therapeutic applications. Graphical Abstract
ISSN:1574-1443
1574-1451
DOI:10.1007/s10904-023-02801-x