Carbonate-β-Cyclodextrin-Based Nanosponge as a Nanoencapsulation System for Piperine: Physicochemical Characterization

• Published in: Journal of soil science and plant nutrition Vol. 19; no. 3; pp. 620 - 630
• Main Authors: Garrido, B., González, S., Hermosilla, J., Millao, S., Quilaqueo, M., Guineo, J., Acevedo, F., Pesenti, H., Rolleri, A., Shene, C., Rubilar, M.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2019; Springer Nature B.V
• Subjects: Agriculture; Bioavailability; Biomedical and Life Sciences; Carbonates; Crosslinking; Cyclodextrins; Ecology; Encapsulation; Environment; Fourier transforms; Life Sciences; Molecular weight; Nanoparticles; Oligosaccharides; Original Paper; Phenols; Piperine; Plant Sciences; Pungent principles; Soil Science & Conservation; Solvents; Spectrum analysis; β-Cyclodextrin; United States > US; China; β-Cyclodextrin; Nanosponges; Piperine; Nanoencapsulation; Inclusion complex; Solvent method
• ISSN: 0718-9508; 0718-9516
• DOI: 10.1007/s42729-019-00062-7

Piperine (PIP) is a nitrogenous substance whose application in food is still limited due to its low solubility in water, low bioavailability, and high pungency. Nanosponges (NS) can selectively capture, transport, and release a wide variety of substances and mask unpleasant flavors. The objective of this study was to evaluate carbonate-β-cyclodextrin-based NS formation as a nanoencapsulation system for PIP. The NS were formed with a cyclic oligosaccharide (β-cyclodextrin) to a cross-linker (diphenyl carbonate) at molar ratios of 1:2, 1:6, and 1:10 by the solvent method at 90, 120, and 150 °C for 5 h. Only molar ratios of 1:6 and 1:10 formed NS. The NS 1:6 at 90 °C with loading efficiency of 42.6% ± 1.1 was the best alternative for loading PIP in the NS matrix because it had the lowest absorbance of cyclic carbonates and required the lowest amount of cross-linker in its formation. The ability of the cyclodextrin-based NS to encapsulate PIP was confirmed by FTIR studies and hyperspectral FTIR images, TGA, and DSC, showing that PIP is dispersed, not forming large clusters, or concentrating in a single zone. NS are an effective PIP encapsulation system and protect the bioactive properties of the PIP.