An improved method for synthesizing N, N′-dicarboxymethylchitosan

• Published in: Carbohydrate polymers Vol. 73; no. 2; pp. 261 - 264
• Main Authors: An, N.T., Dung, P.L., Thien, D.T., Dong, N.T., Nhi, T.T.Y.
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 19.07.2008; Elsevier; Elsevier Science
• Subjects: alkylation; Applied sciences; bone formation; Chelating agent; chelating agents; chemical substitution; Chemistry; Chemistry, Applied; Chemistry, Organic; chitosan; Exact sciences and technology; Michael addition; N, N′-Dicarboxymethylchitosan; N-Monocarboxymethylchitosan; Natural polymers; Osteogenesis agent; Physical Sciences; Physicochemistry of polymers; Polymer Science; Science & Technology; Starch and polysaccharides; substituted chitosan derivatives; synthesis; Water-soluble chitosan; Osteogenesis agent; Chelating agent; N-Monocarboxymethylchitosan; Water-soluble chitosan; N, N′-Dicarboxymethylchitosan; water-soluble chitosan; N-monocarboxymethylchitosan; osteogenesis agent; chelating agent; N,N '-dicarboxymethylchitosan; Molecular structure; Experimental study; N,N'-Dicarboxymethylchitosan; Polyelectrolyte; Chemical modification; Chitosan derivatives; Preparation; Carboxymethylation; Oside polymer; Polyacid; Chitosan
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2007.11.025

Fully substituted N, N′-dicarboxymethylchitosan was obtained by the alkylation of chitosan at pH 8–8.5 and 90 °C using a monochloroacetic acid:chitosan weight ratio of 4:1. The water-soluble derivative is a chelating agent suitable for treatment of osteogenis or other applications involving chelation.