Recombinant OB-Gene Product Reduces Food-Intake in Fasted Mice

• Published in: Biochemical and biophysical research communications Vol. 214; no. 1; pp. 131 - 136
• Main Authors: Rentsch, J., Levens, N., Chiesi, M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.09.1995
• Subjects: adipocytes; adipose tissue; amino acid sequences; Animals; Base Sequence; Cloning, Molecular; DNA Primers; Energy Intake - drug effects; Escherichia coli; Escherichia coli - genetics; Fasting; Feeding Behavior - drug effects; food intake; gene expression; genes; genetic transformation; Leptin; Male; Mice; Molecular Sequence Data; obesity; Obesity - genetics; Proteins - genetics; Proteins - pharmacology; Recombinant Proteins - genetics; Recombinant Proteins - pharmacology; Satiation - drug effects; satiety; satiety factors; white adipose tissue

The ob-gene encodes for a protein of 167 amino acids which is expressed exclusively in white adipose tissue. The ob-gene product is probably released from adipocytes as a soluble hormone of 146 amino acids and has been proposed as a satiety factor. To test this hypothesis, the soluble portion of the...