Microwave-assisted Synthesis of Hybrid Heterocycles as Potential Anticancer Agents

In a one pot procedure, a series of novel hybrid heterocycles 6a-g and 7a-g were prepared by condensation of (3aS,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde 5 with mercapto acids and primary amines in the presence of...

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Published inActa chimica Slovenica Vol. 64; no. 2; pp. 319 - 331
Main Authors Srinivas, Avula, Sunitha, Malladi, Raju, Kammachichu, Ravinder, Banothu, Anusha, Siluveru, Rajasri, Thallapalli, Swapna, Pothuganti, Sushmitha, Dupa, Swaroopa, Deva, Nikitha, Gurala, Rao, Govind, Chakunta
Format Journal Article
LanguageEnglish
Published Slovenia Slovenian Chemical Society 01.06.2017
Subjects
anticancer activity
Antineoplastic Agents - chemistry
click reaction
cyclisation
D-Mannose
Magnetic Resonance Spectroscopy
Microwaves
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Summary:In a one pot procedure, a series of novel hybrid heterocycles 6a-g and 7a-g were prepared by condensation of (3aS,4S,6S,6aS)-6-((1-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbaldehyde 5 with mercapto acids and primary amines in the presence of ZnCl2 under both microwave irradiation and conventional heating conditions. Compound 5 was prepared from di-acetone D-mannose via a click reaction, primary acetonide deprotection and oxidative cleavage. Characterization of new compounds has been done by IR, NMR, MS and elemental analysis. Anticancer activity of the compounds has also been evaluated.
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ISSN:1318-0207
1318-0207
1580-3155
DOI:10.17344/acsi.2016.3153