Enantiodiscrimination by matrix-assisted DOSY NMR

High-resolution NMR is an essential technique for structure determination; however, stereochemistry assignment is still an obstacle. Several methods are known to overcome this limitation but usually at high costs or using derivatizations. Here we describe the use of different solvating agents to vir...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 55; no. 59; pp. 8611 - 8614
Main Authors Salome, Kahlil Schwanka, Tormena, Cláudio Francisco
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 18.07.2019
Subjects
Enantiomers
NMR
Nuclear magnetic resonance
Stereochemistry
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Summary:High-resolution NMR is an essential technique for structure determination; however, stereochemistry assignment is still an obstacle. Several methods are known to overcome this limitation but usually at high costs or using derivatizations. Here we describe the use of different solvating agents to virtually discriminate the enantiomers of 15 analytes using 1 H and 19 F-{ 1 H} DOSY NMR. This article describes the enantiodiscrimination of analytes using low price CSAs and Matrix-Assisted 1 H and 19 F-{ 1 H}-DOSY NMR.
Bibliography:Electronic supplementary information (ESI) available. See DOI
10.1039/c9cc04268g
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc04268g