A new chromone from the twig of Mallotus apelta

A new chromone, 7-hydroxy-2-hydroxymethyl-8-methoxy-4-oxo-4H-chromene-6-carboxylic acid, named melachromone, along with 13 known compounds (2-14), including chromones, flavonoids, coumarins and phenylpropane derivatives, were isolated from the twig of Mallotus apelta. Their chemical structures were...

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Bibliographic Details
Published inNatural product research Vol. 28; no. 21; pp. 1864 - 1868
Main Authors Lu, Tailiang, Deng, Shengping, Li, Chen, Wu, Liangdeng, Yang, Ruiyun, Li, Jun
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.01.2014
Subjects
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
chromone
Chromones - chemistry
Chromones - isolation & purification
cytotoxic activity
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
HeLa Cells
Humans
Inhibitory Concentration 50
Mallotus
Mallotus apelta
Mallotus Plant - chemistry
melachromone
Nuclear Magnetic Resonance, Biomolecular
Mallotus apelta
cytotoxic activity
melachromone
Mallotus
chromone
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Summary:A new chromone, 7-hydroxy-2-hydroxymethyl-8-methoxy-4-oxo-4H-chromene-6-carboxylic acid, named melachromone, along with 13 known compounds (2-14), including chromones, flavonoids, coumarins and phenylpropane derivatives, were isolated from the twig of Mallotus apelta. Their chemical structures were elucidated by using various spectroscopic methods. Anti-tumour evaluation of the compounds suggested that compound 1 exhibited medium cytotoxic activity against KB and HeLa Cells, with IC 50 values of 9.50  and 9.23 μg mL − 1 , respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2014.951853