The ICT-based fluorescence and colorimetric dual sensing of endogenous hypochlorite in living cells, bacteria, and zebrafish

• Published in: Analyst (London) Vol. 145; no. 1; pp. 29 - 33
• Main Authors: He, Xiaojun, Xu, Chuchu, Xiong, Wei, Qian, Yuna, Fan, Jinyi, Ding, Feng, Deng, Hui, Chen, Hong, Shen, Jianliang
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 16.12.2019
• Subjects: Aniline Compounds - chemistry; Aniline Compounds - toxicity; Animals; Bacteria; Cell Line; Cells (biology); Chemical sensors; Chemoreceptors; Colorimetry; Colorimetry - methods; Escherichia coli - metabolism; Fluorescence; Fluorescent Dyes - chemistry; Fluorescent Dyes - toxicity; Humans; Hypochlorous Acid - analysis; Hypochlorous Acid - metabolism; Limit of Detection; Microscopy, Confocal - methods; Microscopy, Fluorescence - methods; Spiro Compounds - chemistry; Spiro Compounds - toxicity; Staphylococcus aureus - metabolism; Zebrafish; Zebrafish - metabolism
• ISSN: 0003-2654; 1364-5528
• DOI: 10.1039/c9an02226k

This work demonstrates a novel chemosensor, SPTPA, that exhibits fluorescence and colorimetric dual sensing of hypochlorite with an ICT ON strategy. Additionally, the chemosensor successfully detected and imaged endogenous hypochlorite in living cells, various types of bacteria, and zebrafish. This work demonstrates a novel chemosensor, SPTPA, that exhibits fluorescence and colorimetric dual sensing of hypochlorite with an ICT ON strategy.