Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing

• Published in: Carbohydrate polymers Vol. 83; no. 2; pp. 705 - 713
• Main Authors: Radhakumary, C., Antonty, Molly, Sreenivasan, K.
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 2011; Elsevier
• Subjects: acrylamides; Antibacterial; antibacterial properties; Applied sciences; bacteria; Biological and medical sciences; chitosan; ciprofloxacin; cold; Controlled release; drugs; Escherichia coli; Exact sciences and technology; General pharmacology; hydrocolloids; ice; Medical sciences; Natural polymers; pain; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; Starch and polysaccharides; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; temperature; Thermoresponsive; Thiolated chitosan; tissue culture; virulence; Wound dressing; Thiolated chitosan; Wound dressing; Antibacterial; Thermoresponsive; Controlled release; Biological properties; Thiol polymer; Cytotoxicity; Drug carrier; Mercaptoacid; Dressing; Wettability; Surface properties; Release; Polymer blends; Swelling; Control release polymer; Mechanical properties; Surface topography; Experimental study; In vitro; Acrylamide derivative polymer; Bactericidal effect; Chemical modification; Free radical polymerization; Chitosan derivatives; Preparation; Oside polymer; Chitosan; Kinetics; Hydrogel; Antibacterial agent; Ciprofloxacin; Fibroblast
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2010.08.042

There is a demand for a wound dressing which can be removed from the application site easily without causing any pain or discomfort. A material removable by manipulating the temperature (e.g. moisten with ice cold water), from that point of view, seems to have considerable potential. Here we report a new formulation consisting of thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin. The thermoresponsive material was cytocompatible and was found to modulate the release of the incorporated ciprofloxacin in a sustained fashion reflecting its suitability to protect a wound for a prolonged period. The film exhibited adequate mechanical strength and was removable from a substrate (e.g. tissue culture plate) by lowering the temperature. The combination of thiolated chitosan with poly(N-isopropyl acrylamide) and ciprofloxacin showed antibacterial properties to the virulent bacteria E coli supporting its potential as a wound dressing.