Drug loaded thermoresponsive and cytocompatible chitosan based hydrogel as a potential wound dressing
There is a demand for a wound dressing which can be removed from the application site easily without causing any pain or discomfort. A material removable by manipulating the temperature (e.g. moisten with ice cold water), from that point of view, seems to have considerable potential. Here we report...
Saved in:
Published in | Carbohydrate polymers Vol. 83; no. 2; pp. 705 - 713 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
2011
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | There is a demand for a wound dressing which can be removed from the application site easily without causing any pain or discomfort. A material removable by manipulating the temperature (e.g. moisten with ice cold water), from that point of view, seems to have considerable potential. Here we report a new formulation consisting of thiolated chitosan with poly(N-isopropyl acrylamide) loaded with ciprofloxacin. The thermoresponsive material was cytocompatible and was found to modulate the release of the incorporated ciprofloxacin in a sustained fashion reflecting its suitability to protect a wound for a prolonged period. The film exhibited adequate mechanical strength and was removable from a substrate (e.g. tissue culture plate) by lowering the temperature. The combination of thiolated chitosan with poly(N-isopropyl acrylamide) and ciprofloxacin showed antibacterial properties to the virulent bacteria E coli supporting its potential as a wound dressing. |
---|---|
Bibliography: | http://dx.doi.org/10.1016/j.carbpol.2010.08.042 |
ISSN: | 0144-8617 1879-1344 |
DOI: | 10.1016/j.carbpol.2010.08.042 |